About 1 in 650-1000 children are born with a 47,XXY, 47,XXX or 47,XYY chromosomal pattern (i.e, sex chromosome trisomies, SCT). The presence of SCT is associated with an increased risk for... Show moreAbout 1 in 650-1000 children are born with a 47,XXY, 47,XXX or 47,XYY chromosomal pattern (i.e, sex chromosome trisomies, SCT). The presence of SCT is associated with an increased risk for neurodevelopmental difficulties across the life-span. Studying neurodevelopment in early childhood in children with SCT could signal deviations in development that serve as risk markers to guide clinical care. This thesis explored the development of self-regulation (emotion, cognition, and behavior) in SCT children and population-based controls, aged 1 to 7 years, who participated in the TRIXY Early Childhood Study. Behavioral symptoms were assessed through structured behavioral observation and parental questionnaires. Neurocognition was measured using performance tests and psychophysiological measures of arousal. Outcomes showed behavioral symptoms of psychopathology and neurocognitive vulnerabilities, already from an early age. Difficulties in self-regulation tended to become more pronounced with increasing age and were rather robust; independent of karyotype, pre/postnatal diagnosis, or intelligence-levels. A developmental neurocognitive perspective is key in increasing our knowledge of gene-brain-behavior pathways in SCT as well as advancing clinical care (diagnostics and treatment). Self-regulation amongst other neurocognitive functions may serve as a valuable target for early, tailor-made interventions to minimize the risk for psychopathology later in life and improving quality of life. Show less
Rostamian, S.; Haan, S. de; Grond, J. van der; Buchem, M.A. van; Ford, I.; Jukema, J.W.; Sabayan, B. 2019
This thesis describes investigations in the neural pathophysiological mechanisms leading to obesity with a specific focus on the relation of brainstructure and function with behaviour and genetics.... Show moreThis thesis describes investigations in the neural pathophysiological mechanisms leading to obesity with a specific focus on the relation of brainstructure and function with behaviour and genetics. Furthermore, it describes investigations in the diagnostic strategy in overweight and obese children. Show less
Stijntjes, M.; Aartsen, M.J.; Taekema, D.G.; Gussekloo, J.; Huisman, M.; Meskers, C.G.M.; ... ; Maier, A.B. 2017
The main focus of the current dissertation is on the associations between self-regulation and academic outcomes, with special attention to these issues in ethnic minority children. Following a... Show moreThe main focus of the current dissertation is on the associations between self-regulation and academic outcomes, with special attention to these issues in ethnic minority children. Following a systematic meta-analysis on the association between cognitive self-regulation and academic achievement regardless of ethnic group, two empirical studies focus on self-regulation and aspects of education in ethnic minority children specifically, examining self-regulatory capacities in relation to educational attainment, and the relation between the transition to primary school and the development of self-regulation. In Chapter 2, flexible thinking that is an important contributor to cognitive self-regulation (i.e., executive function), was found to be positively and substantially related to math and reading performance. The findings of Chapter 3 showed that behavioral self-regulation (i.e., effortful control) is related to educational attainment with respect to secondary school tracks via self-efficacy in Turkish minority preadolescents. Chapter 4 provided evidence that children showed differential gains in flexible thinking from kindergarten to formal schooling, as less able children made more progress following the transition. The findings provided evidence for the important role of self-regulation in school performance and for the role of the transition to formal schooling in shaping the development of higher-order cognitive processes that contribute to self-regulation. Show less
The development of self-regulation is one of the major challenges of a child’s healthy development. In the current thesis, the contribution and interplay of parental and biological factors in... Show moreThe development of self-regulation is one of the major challenges of a child’s healthy development. In the current thesis, the contribution and interplay of parental and biological factors in the development of self-regulation in preschoolers are studied in a large population-based cohort, the Generation R Study. We found that attachment insecurity in infancy was related to higher levels of toddler active resistance during Clean-Up. Maternal negative discipline was related to lower levels of committed compliance in toddlers, and the association between maternal positive discipline and child committed compliance was moderated by the child’s COMT rs4680 genotype, indicating that the association was stronger in children with the Met/Met variant than for children with other COMT genotypes. Maternal family-related stress during pregnancy predicted lower levels of toddler committed compliance through lower levels of maternal positive discipline. Maternal sensitivity was associated with lower levels of executive function problems and lower levels of internalizing problems in preschool age. In children with a relatively short corpus callosum in infancy, higher levels of maternal positive discipline predicted lower levels of inhibition problems. Our studies demonstrate the role of various aspects of positive parenting and mother-child relationship quality in preschool children’s regulation of emotions and behavior. Show less
