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(1 - 3 of 3)
Early identification and resolution of rheumatoid arthritis
Boeters, D.M. 2020
Early identification and resolution of rheumatoid arthritis
Doctoral Thesis
open access
2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z; 2020-09-16T00:00:00Z
  • overzicht van verschillende voorspellers voor het ontwikkelen van RA binnen patiënten met artralgie
  • rol van nieuwe autoantistoffen en MRI in vroege diagnostiek RA
  • onderzoek naar behalen van DMARD...

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  • overzicht van verschillende voorspellers voor het ontwikkelen van RA binnen patiënten met artralgie
  • rol van nieuwe autoantistoffen en MRI in vroege diagnostiek RA
  • onderzoek naar behalen van DMARD-vrije remissie: voorkomen van immunologische remissie en identificatie van subgroep van RA-patiënten met verhoogde kans op remissie

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The use of MRI in early inflammatory arthritis
Nieuwenhuis, W.P. 2018
The use of MRI in early inflammatory arthritis
Doctoral Thesis
open access
Studies in this thesis focused on the use of MRI in patients with early inflammatory arthritis. Studies were focused on: the diagnostic value of MRI, predictive value of MRI findings for the... Show moreStudies in this thesis focused on the use of MRI in patients with early inflammatory arthritis. Studies were focused on: the diagnostic value of MRI, predictive value of MRI findings for the development of erosions, associations between age and MRI findings, the use of MRI for the development of new disease activity scores and patient reported outcomes in patients with rheumatoid arthritis. Show less
Osteoarthritis: the role of synovitis
Kortekaas, M.C. 2015
Osteoarthritis: the role of synovitis
Doctoral Thesis
open access
2016-07-13T00:00:00Z; 2016-01-13T00:00:00Z; 2015-01-16T00:00:00Z; 2016-07-13T00:00:00Z; 2016-07-13T00:00:00Z
Osteoarthritis is a prevalent disease causing pain and disability. It__s aetiology is unknown and no curative treatment is available. Osteoarthritis research is complicated due to heterogeneity of... Show moreOsteoarthritis is a prevalent disease causing pain and disability. It__s aetiology is unknown and no curative treatment is available. Osteoarthritis research is complicated due to heterogeneity of the disease, slow progression and poor association of clinical features with radiographic abnormalities, imaging modality of choice until now. In this thesis the role of synovitis in osteoarthritis is studied in relationship with clinical features and structural damage. The studies described made especially use of data derived a prospective follow-up study in symptomatic hand osteoarthritis patients. Synovitis detected on ultrasound was associated with clinical features and with progression of structural damage after 2.3 years in hand osteoarthritis. In erosive osteoarthritis, a subtype of hand osteoarthritis, more synovitis was found in all hand joints, even in non-erosive joints, when compared to joints of patients without erosive osteoarthritis. Also, associations were found between synovitis and erosive development at follow-up. All analyses were performed on joint level, using GEE analyses, thereby taking into account patient effects. Associations were poor/absent when analyses were done on patient level. This is important for further research. These results indicate that synovitis plays a role in pain and in development of structural damage in osteoarthritis and could be a therapeutic target. Show less