Eating problems are common among children with Autism Spectrum Disorder (ASD), but it is unknown to what extent infant eating behavior is associated with later autistic traits. As eating behavior... Show moreEating problems are common among children with Autism Spectrum Disorder (ASD), but it is unknown to what extent infant eating behavior is associated with later autistic traits. As eating behavior is currently not included in ASD screening instruments, it is important to evaluate whether infant eating behavior predicts later autistic traits and might therefore be used to enhance the early detection of ASD. We investigated the association of breast-feeding and eating behavior during infancy with later autistic traits in the population-based Generation R cohort. We included 3546 mother-child dyads with maternal reports on feeding and eating at age two months and autistic traits at six years. Eating behavior was assessed with seven items on specific eating habits and the Social Responsiveness Scale was used to evaluate autistic traits. Covariates included child sex, and maternal psychopathology and autistic traits. Linear regression analyses showed that being formula fed at two months was associated with a higher autistic trait score at six years (adjusted B = 0.07; 95% CI: 0.00-0.14). Children who were drinking only small quantities (adjusted B = 0.17, 95% CI: 0.04-0.30) and were hungry/not satisfied (adjusted B = 0.23, 95% CI: 0.08-0.39) at age two months also had a higher autistic traits score at age six years. We found no interactions with sex or breastfeeding. This study shows that eating behavior during infancy is related with autistic traits in childhood. Although the associations were fairly small, these findings suggest that early-life eating problems might be relevant for early detection of ASD and a potential addition to ASD-specific screening instruments. Show less
Hof, M.V. van 't; Ester, W.A.; Serdarevic, F.; Berckelaer-Onnes, I. van; Hillegers, M.H.J.; Tiemeier, H.; ... ; Jansen, P.W. 2020
Children with Autism Spectrum Disorder (ASD) often exhibit problematic eating behaviors, an observation mostly based on male dominated, clinical ASD study samples. It is, however, important to... Show moreChildren with Autism Spectrum Disorder (ASD) often exhibit problematic eating behaviors, an observation mostly based on male dominated, clinical ASD study samples. It is, however, important to evaluate both children with an ASD diagnosis and children with subclinical autistic traits as both often experience difficulties. Moreover, considering the suggestion of a possible girl-specific ASD phenotype, there is a need to determine whether autistic traits are related with problematic eating behaviors in girls as well. This study explores the sex-specific association between autism (both autistic traits and diagnosed ASD) and eating behavior in middle childhood in Generation R, a prospective population-based cohort from fetal life onwards. We collected parental reports of autistic traits at six years (Social Responsiveness Scale) and of eating behavior at ten years (Children's Eating Behaviour Questionnaire). In this cohort of 3559 children, autistic traits at six years were associated with more Picky Eating, Emotional Eating and Food Responsiveness in later childhood (e.g. adjusted B for Picky Eating = 0.07; 95% CI: 0.03, 0.11). Stratified analyses showed that in girls, autistic traits were associated with more Emotional Overeating and Emotional Undereating (e.g. adjusted B for Emotional Undereating= 0.12; 95% CI: 0.04, 0.20), while no associations were found for boys. Results comparing children with and without an ASD diagnosis in the cohort largely confirm these associations (e.g. in girls, adjusted B for Emotional Undereating = 0.72; 95% CI: 0.01, 1.42). Our results point to a sex-specific association between autism and eating behavior in middle childhood. Also, our study is the first study to show that autistic traits are associated with emotionally based eating problems in girls and possibly represent part of a girl-specific ASD phenotype. Show less
This thesis is divided into to two parts. The first part investigates the effects of the pharmaceutical gamma-hydroxybutyrate (GHB), also known as sodium oxybate (Xyrem), in various clinical... Show moreThis thesis is divided into to two parts. The first part investigates the effects of the pharmaceutical gamma-hydroxybutyrate (GHB), also known as sodium oxybate (Xyrem), in various clinical populations, including individuals with Parkinson’s disease. Most of research in part one investigates GHB in those with the condition of narcolepsy. The effects of GHB on sleep parameters, including sleep quality, is a key focus point. Other chapters explore the hormonal phenotype of narcolepsy and the impact GHB has on the hormones leptin and ghrelin in both narcolepsy and health controls. Gamma-hydroxybutyrate has a history of abuse and know abuse liability. Chapter 5 in this thesis explores the how illicit GHB and Xyrem differ in their abuse potential and incidence. Part two of the thesis focuses on how various aspects of lifestyle influence metabolism and indicators of health status. In Chapter 9, eating behavior is evaluated in response to ecologically relevant amounts of sleep loss common experienced by average people in the modern world. In Chapter 10, we explore how health young adults respond to a four-day, Paleolithic theory-themed nature trip in the German countryside. Show less
