A large part of this thesis focussed on the additional value of MRI in the early detectionof RA. In contrast to showing its additional value, we also found that MRI can alsobe too sensitive and... Show moreA large part of this thesis focussed on the additional value of MRI in the early detectionof RA. In contrast to showing its additional value, we also found that MRI can alsobe too sensitive and appoint patients with MRI-detected inflammation that never willgo on to develop imminent, chronic RA. In clinical practise the exact role of imagingfor the early detection of RA still needs to be established further. Also the causes ofinflammation at MRI in patients with CSA or early IA are not fully understood yet. Itneeds to be specified in which individual patients, MRI has the most beneficial effectsand in combination with which clinical characteristics. In addition to this, also its costeffectiveness needs to be determined. The second part of this thesis focused more on subjective components of the disease, which is highly valuable for patients’ themselves.But next to this, a patients’ perspective is increasingly being taken into account fordecisions on treatment options. Although current treatment strategies have resulted inimproved disease outcomes and chronic damage can be prevented in a large amount ofpatients, patients still experience problems in daily life and at work. As we observed thatdespite improved therapies, many important outcomes remain present, like fatigue andpain, these should also be incorporated in future treatment aims as they pose a burdenon patients’ wellbeing as well as on society. Show less
