This book is about the creation and enforcement of labour law in Indonesia, a topic that reflects the broader processes of social and political change in the country. Its starting point is... Show more This book is about the creation and enforcement of labour law in Indonesia, a topic that reflects the broader processes of social and political change in the country. Its starting point is the notion of the trade union as a crucial institution in any modern industrial capitalist society, with the potential of promoting some measure of equity and social justice in society. The book discusses three case-studies relating to three major pieces of labour legislation enacted since the Reformasi of 1998 in Indonesia. The first is about trade union legislation, the second about minimum wage policy, and the third about the Industrial Relations Court. These cases show how labour law in Indonesia is best understood as the result of the struggles between different social groups and competing ideologies, which change over time. The author argues that despite all the problems and challenges there remains hope for the development of a sound and effective labour law in Indonesia. This is due in particular to the development of the trade union movement in the country. Unions form a countervailing power against capital and corporate power, and may thus ensure that the results of development are redistributed fairly throughout society. They are also agents of education: their efforts to develop new labour laws and enforce labour standards make workers aware of their rights and may even help in developing a higher degree of rights-consciousness in society more generally. This book is about the creation and enforcement of labour law in Indonesia, a topic that reflects the broader processes of social and political change in the country. Its starting point is the notion of the trade union as a crucial institution in any modern industrial capitalist society, with the potential of promoting some measure of equity and social justice in society. The book discusses three case-studies relating to three major pieces of labour legislation enacted since the Reformasi of 1998 in Indonesia. The first is about trade union legislation, the second about minimum wage policy, and the third about the Industrial Relations Court. These cases show how labour law in Indonesia is best understood as the result of the struggles between different social groups and competing ideologies, which change over time. The author argues that despite all the problems and challenges there remains hope for the development of a sound and effective labour law in Indonesia. This is due in particular to the development of the trade union movement in the country. Unions form a countervailing power against capital and corporate power, and may thus ensure that the results of development are redistributed fairly throughout society. They are also agents of education: their efforts to develop new labour laws and enforce labour standards make workers aware of their rights and may even help in developing a higher degree of rights-consciousness in society more generally. Show less
Primordial germ cells (PGCs) are the progenitors of the gametes, responsible for transmitting genetic information from generation to generation. Although there is a long history of gamete biology... Show morePrimordial germ cells (PGCs) are the progenitors of the gametes, responsible for transmitting genetic information from generation to generation. Although there is a long history of gamete biology research, there is still a lot to be learned about many of the mechanisms underlying germ cell development. This dissertation describes and discusses the dynamics of PGCs in the chicken, with a focus on their migration to the gonads and meiosis that takes place when PGCs are already settled there. We also discussed the advantages of using the avian model in epithelial ovarian cancer research. Moreover, we revisited an often overlooked model for amniogenesis in which the proamnion plays a crucial role. Show less
The embryonic development of the human cochlea (the organ of hearing) has been investigated for over one hundred years. However, little is still known about the development on a cellular and... Show moreThe embryonic development of the human cochlea (the organ of hearing) has been investigated for over one hundred years. However, little is still known about the development on a cellular and protein level, which is important to better understand etiologies and pathologies of various types of sensorineural hearing loss. Knowledge of the normal gene expression patterns and cell fate specification in the human cochlea has therefore the potential to aid in the development of gene and cell-based therapeutic strategies. For this reason, we acquired a series of human fetal cochlea of different stages of gestation and investigated several aspects of the normal development of the human cochlea such as the hair cells, the spiral ganglion neurons and the stria vascularis. Also, we investigated the neural crest stem cells residing in the hair follicle bulge. We showed that a protein (TUBB3) often used in immunochemistry to detect a neuron is also expressed both in skin and hair follicle melanocytes in humans meaning that the proposed neural crest stem cell residing in the hair follicle bulge might need revision. Show less
Children and adolescents who are chronically rejected by their peers suffer from widespread impairments in daily life, ranging from poor academic achievement and dropping out of school, to... Show moreChildren and adolescents who are chronically rejected by their peers suffer from widespread impairments in daily life, ranging from poor academic achievement and dropping out of school, to delinquency and the development of mental health problems. To gain a better understanding of the developmental processes that give rise to such impairments, the research described in this dissertation examined the neurocognitive underpinnings of processes that play a role in the emergence and maintenance of peer group rejection and acceptance. The first part of this dissertation focuses on neurocognitive processes underlying reactions to social exclusion. The second part concentrates on the neurocognitive processes involved in sharing valuable resources, based on the widely established finding that frequent displays of prosocial behaviors, such as cooperating, helping, and sharing, are associated with both gaining and maintaining acceptance among peers. The empirical work in this dissertation demonstrates that a developmental cognitive neuroscience approach provides unique insights into the emotional, regulatory, and socio-cognitive processes thought to play a role in the emergence and maintenance of peer group acceptance and rejection. Show less
Self-control abilities are crucial for successful functioning in daily life. At the core of self-control lies the ability to intentionally inhibit one__s actions. Intentional inhibition differs... Show moreSelf-control abilities are crucial for successful functioning in daily life. At the core of self-control lies the ability to intentionally inhibit one__s actions. Intentional inhibition differs from externally driven inhibition in that it is driven by an internal thought process rather than an external stimulus that tells one to stop. The goal of this thesis was to examine the development of intentional inhibition and compare this with externally driven inhibition. In order to investigate the covert process of intentional inhibition, the research described in this thesis made use of neurobiological measures such as phasic heart rate changes and functional magnetic resonance imaging (fMRI). In addition, to learn more about self-control in context, the final empirical chapter examined intentional and externally driven inhibition in the context of relevant and irrelevant emotions. Show less
The main focus of the research that makes up this thesis was to translate rodent behavioural assays to larval zebrafish for better time and resource management in biomedical research,... Show moreThe main focus of the research that makes up this thesis was to translate rodent behavioural assays to larval zebrafish for better time and resource management in biomedical research, pharmaceutical research and development. __The larval zebrafish is a useful model in toxicology and drug discovery. However, its predictivity is restricted by compound class. __Light-dark cycle plays an important role in the normal development of the zebrafish embryo, and abnormal lighting regimes during rearing can result in malformations. __The hyperactivity displayed by zebrafish larvae following the onset of sudden darkness is an intrinsic characteristic. Zebrafish larvae quickly habituate with repeated stimuli of onset of darkness with short interstimulus interval. __Zebrafish larvae are able to discriminate colours, and they show a preference for orange and green, but aversion towards red, yellow, blue and black. The larvae also show freezing behaviour in the complex environment which is attenuated with diazepam.. __Zebrafish larvae raised in an abnormal lighting regime changed some aspects of their colour preference, although orange and red remained as preferred and avoided colours respectively. __In short, the zebrafish larvae is a useful complementary animal model in behavioural research amenable to high-throughput screening of compounds and drug discovery Show less
In the Netherlands, information provision about fertility preservation (FP) for young women with breast cancer is not sufficient. Since an increasing number of Dutch breast cancer patients will... Show moreIn the Netherlands, information provision about fertility preservation (FP) for young women with breast cancer is not sufficient. Since an increasing number of Dutch breast cancer patients will face this preference-sensitive decision each year, there is a clear need for improvement of information provision about FP. The overall aim of this thesis was therefore to (a) develop and (b) evaluate a Decision Aid (DA) about FP that is targeted to improve information provision and decision making about FP for young women with breast cancer. This thesis describes consecutively the development and evaluation of such a DA with values clarification exercise (VCE) Show less
We examined the development of international adoptees from infancy to young adulthood, and factors influencing developmental outcomes in middle childhood, adolescence and young adulthood. The... Show moreWe examined the development of international adoptees from infancy to young adulthood, and factors influencing developmental outcomes in middle childhood, adolescence and young adulthood. The results for cognitive development (Chapter 2) showed that early malnutrition influenced cognitive and health-related outcomes, but its consequences did not extend to socioeconomic success later in life. The human brain seems capable of adapting to changing environmental influences, but earlier placement in a positive family environment should be preferred (see also Chapter 1). The adoptees in the Leiden Longitudinal Adoption Study were exposed to few adversities due to their early adoptive placement, and the combination with the nurturing environment of a permanent adoptive family resulted in positive cognitive and socio-emotional outcomes (Chapters 2 and 3). Our results for longitudinal (sensitivity) and concurrent relations (reactivity to infant crying) with attachment representations in young adulthood (Chapters 3 and 4) clearly point to this role of the family environment in predicting social-emotional outcomes. High parenting quality is important, also in families where children do not share a common genetic basis with their parents. In sum, adoption can be seen as a positive intervention and the (adoptive) family environment matters for children growing up from infants to young adults. Show less
Core deficits in people with autisme spectrum disorders (ASD) are difficulties in adapting their behaviour to the social environment which hampers the possibilities to communicate adequately and to... Show moreCore deficits in people with autisme spectrum disorders (ASD) are difficulties in adapting their behaviour to the social environment which hampers the possibilities to communicate adequately and to have reciprocal relationships. These problems have a serious impact on functioning in their daily life. Since ASD are severe and lifelong conditions, it is relevant to examine how children with ASD develop troughout their life and to investigate which factors constitute an unfavourable contribution to their development. This thesis reveals that children with ASD are at specific risk of poor quality of life in adulthood when compared to children with other psychiatric disorders. Secondly, the impact of ASD on specific domains of intellectual functioning is different at different ages, implicating that re-evaluation of cognitive function during development of children with ASD is recommended during their life. Thirdly, children with ASD who are at risk of schizophrenia spectrum pathology, may show negative schizotypal symptoms, but also disorganized and positive symptoms in addition to ASD symptomatology. These symptoms of schizotypy appear to be associated with inhibition problems. We should be aware of inhibition problems in children with ASD because they may be indicators of high risk to schizophrenia spectrum pathology later in life. Show less
This thesis is a study on the link between early development and adult health. Studies in animal models indicate that so-called epigenetic marks may be influenced by nutrition during development,... Show moreThis thesis is a study on the link between early development and adult health. Studies in animal models indicate that so-called epigenetic marks may be influenced by nutrition during development, changing the expression of genes implicated in disease. Epigenetics may therefore link development and disease. To investigate this hypothesis in humans we studied DNA methylation, a key epigenetic mark, in individuals exposed during early gestation to the Dutch Famine and individuals born growth restricted, which is also alleged to relate to malnutrition. DNA methylation at metabolic and developmental genes was associated with early gestational famine exposure to the Dutch Famine and the patterns of the associations mirrored the epidemiological findings. The associations found with prenatal famine exposure did not relate to prenatal growth restriction, adding evidence that prenatal growth restriction is not linked with m alnutrition in Western cohorts. Further characterization showed that DNA methylation differences associated with prenatal famine exposure are independent of genetic variation, cluster along biological pathways and within regulatory regions and may relate to the phenotypic consequences of prenatal malnutrition. The work described in this thesis gives credence to the hypothesis that epigenetic marks may be the molecular link between development and later disease in humans Show less
This study analyses the encyclical Caritas in veritate as a new encyclical in the ongoing development of the __social doctrine__ of the Roman Catholic Church. In this regard, the research questions... Show moreThis study analyses the encyclical Caritas in veritate as a new encyclical in the ongoing development of the __social doctrine__ of the Roman Catholic Church. In this regard, the research questions are: to what extent is Caritas in veritate continuous with earlier pronouncements? To what extent is it new? In as far as there are new elements, can these be understood in relation to the theological thought of Joseph Ratzinger, who became pope Benedict XVI? To what extent can the specific points of view present in Caritas in veritate be seen as responses to contemporary social and economic developments such as globalization, or to new insights in the human sciences and contemporary secular thought? Show less
In this thesis, four studies on children and adolescents with Down syndrome are described. The first study showed that the number of live births of children with Down syndrome in the Netherlands... Show moreIn this thesis, four studies on children and adolescents with Down syndrome are described. The first study showed that the number of live births of children with Down syndrome in the Netherlands remained stable over the period 1997-2007 on 14.6 per 10,000 births. Of these, 85% were live born. In the second study is observed that growth retardation in children with Down syndrome meanly occurs in three critical periods of growth, resulting in shorter final stature and smaller head circumference than the general Dutch population shows. Furthermore, Dutch children with Down syndrome have alarmingly high prevalence rates of overweight and obesity during childhood and adolescence. The third study showed that eight-year-old children with Down syndrome have an average developmental delay of four years, more often have emotional and behavioral problems, and have a less favorable health-related quality of life (HRQoL) compared with children from the general population. Children with Down syndrome and recurrent respiratory tract infections showed relatively more delayed development. In the fourth study, results showed that adolescents with Down syndrome remain dependent to a large degree and have serious difficulties in functioning socially. Additionally, results showed that serious problem behavior is highly prevalent in adolescents with Down syndrome. Show less
This thesis provides a comparison of mostly perceptual development during vocal learning in songbirds (zebra finches) and human infants. The aim is to disentangle experience dependent and... Show moreThis thesis provides a comparison of mostly perceptual development during vocal learning in songbirds (zebra finches) and human infants. The aim is to disentangle experience dependent and independent processes during vocal learning. In both human infants and juvenile songbirds, a perceptual preference for __universal__ sounds was found, independent of adult auditory input. Later in development, both infants and juvenile songbirds show a change is preference. The juvenile songbirds clearly change their preference towards sounds they have been auditorily exposed to (chapter 3). In human infants in the influence of experience is less clear in this thesis. In combination with previous literature the most likely scenario is a combination of experience dependent and independent processes (chapter 2). To further compare human and birdsong phonology, a __typology__ of zebra finch song elements was performed (chapter 4). The results of this study indicate commonality as well as variation between populations in terms of phonology. In the order of elements within a sequence however, there is little evidence for common patterns across populations and there is variation within and between populations. In summary, this thesis shows similarities in developmental mechanisms in two vocally learning species. There might be a link between development and typology. Show less
Ma, B.; Landman, E.B.M.; Miclea, R.L.; Wit, J.M.; Robanus Maandag, E.C.; Post, J.N.; Karperien, M. 2013
