Aim of the dissertation: To expand the knowledge on the behavioural phenotypes, level of parenting stress and the relationship between child characteristics and parenting stress in five genetic... Show moreAim of the dissertation: To expand the knowledge on the behavioural phenotypes, level of parenting stress and the relationship between child characteristics and parenting stress in five genetic syndromes. The included syndromes are Angelman, CHARGE, Cornelia de Lange, Prader-Willi, and Rett syndrome. All syndromes are associated with intellectual disabilities. Method: Participants were children and adults with one of the syndromes and their parents, recruited through the Dutch Parent Support Groups. Parents filled out questionnaires concerning parenting stress and behavioural characteristics of their child. Additionally an interview regarding autistic traits of the child was administrated with parents. Main results: The behavioural phenotypes of the syndromes are described in detail. In all syndromes there is a high risk to display autistic traits. The syndromes can been seen as a risk factor for high levels of parenting stress. Specialized psycho-education on the behavioural strengths and weaknesses of a specific syndrome should be given to parents. Awareness on the high prevalence of autistic traits is important to be able to shape an optimum adaptive environment. Professionals should not only focus on the child with the syndrome, but also on the family system given the high stress levels for parents. Show less