This paper presents the initial report of our “Karakorum Rescue Project 2020-21” in the Gilgit-Baltistan region of Pakistan. The petroglyphs of the Karakorum Mountains are very important as it was... Show moreThis paper presents the initial report of our “Karakorum Rescue Project 2020-21” in the Gilgit-Baltistan region of Pakistan. The petroglyphs of the Karakorum Mountains are very important as it was crucial crossroads throughout ancient times and different routes were used by a wide diversity of merchants, travellers, caravans and pilgrims for thousands of years. These rock art sites in the region are in danger due to the construction of dam, destruction and vandalism of especially the Buddhist rock art continue to threaten the existence of these historical petroglyphs, including many that have as yet never been documented before. For the preservation and documentation of this heritage, we initiated this project with the support of the Prince Claus Heritage Emergency Grant and the Aliph Alliance. This helps us to outline the academic and fieldwork strategies we used and how we combined a (non-invasive) archaeological photographical rescue campaign with an active and inclusive outreach to the local communities of the research region. Show less
Harskamp, R.E.; Himmelreich, J.C.L.; Wong, G.W.M.; Teichert, M. 2021
Objectives To describe the prevalence, temporal and regional trends in prescribing direct oral anticoagulants (DOACs) in conjunction with interacting medications. Methods We performed a cross... Show moreObjectives To describe the prevalence, temporal and regional trends in prescribing direct oral anticoagulants (DOACs) in conjunction with interacting medications. Methods We performed a cross-sectional study of pharmacy dispensing data in the Foundation for Pharmaceutical Statistics (SFK) registry on patients who have had a prescription for a DOAC filled at one of 831 randomly selected pharmacies in the Netherlands between Jan 2014-Jan 2019. Results We identified 99,211 patients who had a first DOAC prescription filled. Mean age was 71.6 +/- 10.9 years, 58% were male. In 2014, 8,293 patients were treated with DOACs, in 2018, 35,415 were newly started on a DOAC. In 2018, the use of apixaban was most common (52%) in the Eastern region, whereas rivaroxaban was most frequently prescribed (32-48%) in the other regions. At time of first prescription, the vast majority (99.3%) used >= 1 concomitant interacting drug, and 3.2% used >= 3 interacting medications. Most common were digoxin (37.8%), atorvastatin (31.5%), verapamil (13.7%) and amiodarone (9.7%). While the number of interacting medications remained unchanged over time (median 1, interquartile range 1-1), there was a notable decrease in antiarrhythmic medications and an increase in non-cardiovascular interacting medications (e.g. dexamethasone from 0.9% to 7.1%, antiepileptic drugs from 2.5% to 3.8%, and haloperidol from 0.5% to 2.2% in 2014 and 2018, respectively). Conclusion DOAC use has quadrupled in Dutch clinical practice over the 5-year period from 2014 to 2018. While the number of patients who take interacting medications remained stable, the profile of interacting medications has changed over time from cardiovascular to medications affecting other organ systems. Show less
Attitudes towards cultural heritage have long been characterised by an ‘endangerment sensibility’ concerned with preventing losses. Recently, however, critical heritage scholars have argued that... Show moreAttitudes towards cultural heritage have long been characterised by an ‘endangerment sensibility’ concerned with preventing losses. Recently, however, critical heritage scholars have argued that loss can be generative, facilitating the formation of new values and attachments. Their arguments have focused primarily on material heritage, whose risk of damage and disappearance is accelerating due to growing environmental crises. After Japan’s 2011 tsunami, however, heritage scholars there began probing a related question: what happens when supposedly ‘intangible’ heritage is damaged? Taking this question as a starting point, I ask how recent applications of assemblage theory in studies of heritage can shed light on destruction's role in forming and reforming places and peoples. Drawing on fieldwork in Japan’s disaster regions, I argue that disassembly is a form of damage rendering both the things mediating heritage and its reciprocal mediation of social life matters of concern. I suggest that the potential of loss lies in how heritage can be made to translate other interests during its reassembly. By contrast, attempts to perpetuate pre-existing relations can render the social more rather than less precarious, depending on the context. Show less
