As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used... Show moreAs leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics. While such metallodrugs are urgent to be improved because they are often accompanied by severe side effects to the patients. Alternatively, ruthenium-based complex are considered as more promising candidates due to their appealing photochemistry and photophysical properties. These properties offer possibility to activate such complex by external light, which realizes a better partial targeting to tumor region and thus reduces the side effect of the metallodrugs. To further optimize the tumor selectivity of ruthenium complexes, in this thesis, a series of ruthenium(Ⅱ) polypyridine-peptide conjugates were synthesized differential in polypyridine ligand, peptide sequence, and/or chirality. Their structure, photochemistry, in vitro cellular behaviors, and in vivo antitumor efficiency, were widely studied and compared. My study confirmed that the conjugation of peptides with ruthenium complexes is one of the most promising tools for improving their potential as clinical drugs, which provides a strong basis for the design and application of more ruthenium-peptide candidates for active tumor targeting in the future. Show less
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam. This new technique,... Show moreIn this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam. This new technique, which we call photothermal circular dichroism microscopy, probes circular dichroism in an absorption measurement, unlike other techniques which usually probe the extinction. We also investigate in detail how to avoid measurement artefacts such as leakage of linear dichroism and residual intensity modulation.We then study the CD of formally achiral and wet-chemically synthesized chiral nanoparticles. We find that the achiral spherical-like particles, can exhibit considerable circular dichroism, some of them display almost as strong CD as specially designed chiral particles. Furthermore, we find that the control of handedness of the synthesized chiral particles is only limited and that, even from a geometric perspective, the relation between the 3D shape of these particles and their handedness is not straightforward.In the last chapter, we apply our method to magnetic samples which exhibit circular dichroism through their magnetization but not due to their shape. The excellent sensitivity of photothermal microscopy not only allows us to perform magnetic imaging of particles, but we also succeeded in obtaining magnetization curves of single particles and estimating their magnetization. Show less
Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence. When a nanoparticle absorbs light,... Show moreGold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence. When a nanoparticle absorbs light, the corresponding energy is converted to heat, which can affect the environment of the (hot) nanoparticle. This thesis uses scattering and photoluminescence to study the behaviour of optically heated single gold nanoparticles: it discusses the behaviour of single plasmonic vapour nanobubbles, which occur around highly heated nanoparticles immersed in a liquid, the detection of chirality in nano-objects through their absorption and the photothermal effect, the behaviour of gold nanoparticles under sub-picosecond pulsed excitation, and the temperature dependence of pulse-excited photoluminescence of such particles. Show less
Geometric frustration occurs when local order cannot propagate through space. A common example is the surface of a soccer ball, which cannot be tiled with hexaganons only. Geometric frustration can... Show moreGeometric frustration occurs when local order cannot propagate through space. A common example is the surface of a soccer ball, which cannot be tiled with hexaganons only. Geometric frustration can also be present in materials. In fact, geometry can act as an instrument to design the mechanical, optical or physical properties of fluids and solids. The first two parts of this thesis discuss frustrated liquid crystals confined to droplets of various shapes and sizes. The droplet shape determines the orientation of the liquid crystal molecules and in turn its response to light. In the final part we study the fracture mechanics of curved elastic plates. By tuning the curvature of the plate, the critical length at which the crack starts growing can be controlled. Finally, we find that the path that the crack takes depends on the curvature. Show less
