Leiden University Scholarly Publications

Kohler, I.; Hankemeier, T.; Graaf, P.H. van der; Knibbe, C.A.J.; Hasselt, J.G.C. van 2017

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine

Article / Letter to editor

open access

Post, J. van der 2006

Biomarkers in early phase development of central nervous system drugs: a conceptual framework

Doctoral Thesis

open access

The main objective of this thesis is to provide a conceptual framework for the use of Central Nervous System (CNS) biomarkers in early phase clinical drug development. In the Introduction the... Show moreThe main objective of this thesis is to provide a conceptual framework for the use of Central Nervous System (CNS) biomarkers in early phase clinical drug development. In the Introduction the current use of biomarkers in early CNS drug development is discussed. A conceptual framework for the classification of biomarkers is suggested, based on general questions that these markers should provide information on. The body of this thesis (Chapters 1-7) exemplifies the use of these markers within this conceptual framework. In the Conclusions and Discussion a critical evaluation of the presented conceptual biomarker framework is give and directions for future biomarker research are offered. Show less