With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality. It is therefore vital that research is focussed on overcoming the... Show moreWith the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality. It is therefore vital that research is focussed on overcoming the most challenging bacterial resistance mechanisms. To this end, the aim of the work described in this thesis was to develop novel strategies to combat resistant bacteria, with particular focus on the threat posed by gram-negative bacteria. Show less
