This thesis shows that an attempt to deprescribe preventive cardiovascular medication in 40 to 70 year old low-risk patients under surveillance of the GP is safe in the short term. The... Show moreThis thesis shows that an attempt to deprescribe preventive cardiovascular medication in 40 to 70 year old low-risk patients under surveillance of the GP is safe in the short term. The deprescribing consultation should be patient-centered in order to optimally judge overtreatment.Decision-making could be improved if more personalised risk scores were available, that assess an individual’s CVD risk and benefit of treatment. Opportunities for future development of these personalised risk scores lie in the use of routinely registered patient data.Overall, this thesis’ findings provide both practical tools for GPs to judge overtreatment in low-risk patients, as well as valuable information for policy makers revising the cardiovascular risk management guideline. Show less