In the thesis I present a series of studies that focus on the use and optimization of use of low-dose ketamine in clinical practice by:(1) reviewing the proof for its use in alleviation and... Show moreIn the thesis I present a series of studies that focus on the use and optimization of use of low-dose ketamine in clinical practice by:(1) reviewing the proof for its use in alleviation and prevention of acute and chronic (cancer and non-cancer) pain;(2) testing a possible novel administration route of ketamine, i.e. inhalation;(3) applying ketamine in a novel indication: the use of the S-enantiomer as respiratory stimulant during opioid-induced respiratory depression;(4) studying the effect of a nitric oxide donor on ketamine (the racemic and S-ketamine variants) typical side effects that hamper it’s use in chronic pain therapy Show less
Pain management in the ICU can be difficult due to lack of patient self report. This thesis describes pain management, including procedural pain in patients in the ICU after cardiac surgery.... Show morePain management in the ICU can be difficult due to lack of patient self report. This thesis describes pain management, including procedural pain in patients in the ICU after cardiac surgery. Chronic pain one year after cardiac surgery is also evaluated and risk factors for the development of chronic pain are identified. Recommendations for the management of acute and procedural pain in patients in the ICU and for the follow-up of chronic pain after cardiac surgery are provided. Show less
Yassen, A.; Passier, P.; Furuichi, Y.; Dahan, A. 2013
