In this paper we consider a spatial discretization scheme with an adaptive grid for the Nagumo PDE and establish the existence of travelling waves. In particular, we consider the time dependent... Show moreIn this paper we consider a spatial discretization scheme with an adaptive grid for the Nagumo PDE and establish the existence of travelling waves. In particular, we consider the time dependent spatial mesh adaptation method that aims to equidistribute the arclength of the solution under consideration. We assume that this equidistribution is strictly enforced, which leads to the non-local problem with infinite range interactions that we derived in Hupkes and Van Vleck (J Dyn Differ Eqn, 2021). Using the Fredholm theory developed in Hupkes and Van Vleck (J Dyn Differ Eqn, 2021) we setup a fixed point procedure that enables the travelling PDE waves to be lifted to our spatially discrete setting. Show less
We consider the question of when delay systems, which are intrinsically infinite dimensional, can be represented by finite dimensional systems. Specifically, we give conditions for when all the... Show moreWe consider the question of when delay systems, which are intrinsically infinite dimensional, can be represented by finite dimensional systems. Specifically, we give conditions for when all the information about the solutions of the delay system can be obtained from the solutions of a finite system of ordinary differential equations. For linear autonomous systems and linear systems with time-dependent input we give necessary and sufficient conditions and in the nonlinear case we give sufficient conditions. Most of our results for linear renewal and delay differential equations are known in different guises. The novelty lies in the approach which is tailored for applications to models of physiologically structured populations. Our results on linear systems with input and nonlinear systems are new. Show less
Graaf, P.H. van der; Benson, N.; Peletier, L.A. 2016
Mathematical analysis of pharmacological models is becoming increasingly rel- evant for drug development. Emphasis on mechanistic models has grown and qualitative understanding of complex... Show moreMathematical analysis of pharmacological models is becoming increasingly rel- evant for drug development. Emphasis on mechanistic models has grown and qualitative understanding of complex biological systems has improved a great deal. In this paper we present two examples of basic modular processes which are involved in a wide range of physiological systems. The first model concerns the interaction of a drug with its target, the way the compounds bind and then elicit an effect. The second model is central in signal trans- duction across the cell wall. Both models demonstrate the complex and interesting dynamics which is directly relevant for the impact of the drug. Show less
