In myelodysplastic syndromes tailoring the timing of bone-marrow transplant according to patient’s genomic profile and characteristics is fundamental since it represents the only curative treatment... Show moreIn myelodysplastic syndromes tailoring the timing of bone-marrow transplant according to patient’s genomic profile and characteristics is fundamental since it represents the only curative treatment available in this disease and it can be per- formed only once. In this work we present a method based on a multi-state model to analytically optimize the timing of the transplant. This method can be used as an alternative to the microsimulation approach based on Monte Carlo. As objective function for the optimization, the Restricted Mean Survival Time was considered together with its first derivative. This decision analysis is the basis for a novel quantitative tool to assist clinicians in their decision process for the treatment of patients affected by this condition. Show less
