High-tech industries power the modern digital world, but their supply chains are particularly vulnerable to geopolitical and economic disruption. Urgent action is needed to improve supply-chain... Show moreHigh-tech industries power the modern digital world, but their supply chains are particularly vulnerable to geopolitical and economic disruption. Urgent action is needed to improve supply-chain resilience. Show less
Sheltering is an immediate human need and determines well-being andhealth. However, we face many challenges in providing homes and offices for allon this rapidly changing planet. In the 21st... Show moreSheltering is an immediate human need and determines well-being andhealth. However, we face many challenges in providing homes and offices for allon this rapidly changing planet. In the 21st century, climate change, resourcecrises, and population expansion will combine to exacerbate existingchallenges. We need to better understand and tackle these issues. Therefore,the overarching research question of this thesis is: What are the mainchallenges and opportunities in delivering decent shelters for nearly 10billion people in a warming and resource-scarce world? To this end, this thesismakes the first steps in exploring several key intersecting challenges relatedto resources scarcity, global warming, and natural hazards. Show less
Streptomycetes are soil-dwelling Gram-positive bacteria and can produce clinical drugs and adapt to environmental fluctuations through diverse morphological changes. The morphological development... Show moreStreptomycetes are soil-dwelling Gram-positive bacteria and can produce clinical drugs and adapt to environmental fluctuations through diverse morphological changes. The morphological development of streptomycetes features apical growth, which is determined by a tip-organizing center containing machinery for the synthesis of a cellulose-like glycan deposited at the cell surface. This thesis demonstrated that the cellulose-like glycan likely cellulose and the related synthesis machinery are unique in comparison with other Gram-negative cellulose synthesis systems. It showed that the synthesis of this glycan is performed by the glycosyltransferase ClsA and matured galactose-oxidase protein GlxA. Subsequently, the lytic polysaccharides monooxygenase LpmP and the glucanase ClsZ, adjacent to CslA/GlxA, cooperatively cleave peptidoglycan and create a passage to assist the exposure of this glycan on cell surface. In addition, this thesis also revealed coordination of polar growth determinants is performed by a stomatin-like protein StlP, which locates in the same gene cluster with CslA/GlxA/CslZ/LpmP. Oligomerization of StlP forms a fluid microdomain at hyphal tips, which spatially confines the whole tip organizing center. Furthermore, this thesis further showed that the cellulose-like glycan of Streptomyces coelicolor is responsible for the aggregation of clumps, which is distinct from Streptomyces lividans where this glycan mediates germlings’ aggregation. Show less
Tukker, A.; Behrens, P.; Deetman, S.P.; Hu, M.; Migoni Alejandre, E.; Meide, M. van der; ... ; Zhang, C. 2023
Building stock growth around the world drives extensive material consumption and environmental impacts. Future impacts will be dependent on the level and rate of socioeconomic development, along... Show moreBuilding stock growth around the world drives extensive material consumption and environmental impacts. Future impacts will be dependent on the level and rate of socioeconomic development, along with material use and supply strategies. Here we evaluate material-related greenhouse gas (GHG) emissions for residential and commercial buildings along with their reduction potentials in 26 global regions by 2060. For a middle-of-the-road baseline scenario, building material-related emissions see an increase of 3.5 to 4.6 Gt CO2eq yr-1 between 2020-2060. Low- and lower-middle-income regions see rapid emission increase from 750 Mt (22% globally) in 2020 and 2.4 Gt (51%) in 2060, while higher-income regions shrink in both absolute and relative terms. Implementing several material efficiency strategies together in a High Efficiency (HE) scenario could almost half the baseline emissions. Yet, even in this scenario, the building material sector would require double its current proportional share of emissions to meet a 1.5 degrees C-compatible target.Building construction causes large material-related emissions which present a serious decarbonization challenge. Here, the authors show that the building material sector could halve emissions by increasing efficiency until 2060 but even then its emissions would be twice as high as needed to meet the 1.5 degrees C target. Show less
Zhong, X.; Hu, M.; Deetman, S.P.; Dias Rodrigues, J.F.; Lin, H.; Tukker, A.; Behrens, P.A. 2021
Energy efficiency plays an essential role in energy conservation and emissions mitigation efforts in the building sector. This is especially important considering that the global building stock is... Show moreEnergy efficiency plays an essential role in energy conservation and emissions mitigation efforts in the building sector. This is especially important considering that the global building stock is expected to rapidly expand in the years to come. In this study, a global-scale modeling framework is developed to analyze the evolution of building energy intensity per floor area during 1971-2014, its relationship with economic development, and its future role in energy savings across 21 world regions by 2060. Results show that, for residential buildings, while most high-income and upper-middle-income regions see decreasing energy intensities and strong decoupling from economic development, the potential for further efficiency improvement is limited in the absence of significant socioeconomic and technological shifts. Lower-middle-income regions, often overlooked in analyses, will see large potential future residential energy savings from energy intensity reductions. Harnessing this potential will include, among other policies, stricter building efficiency standards in new construction. For the commercial sector, during 1971-2014, the energy intensity was reduced by 50% in high-income regions but increased by 193% and 44% in upper-middle and lower-middle-income regions, respectively. Given the large energy intensity reduction potential and rapid floor area growth, commercial buildings are increasingly important for energy saving in the future. (C) 2021 The Author(s). Published by Elsevier Ltd. Show less
Zhang, C.; Hu, M.; Sprecher, B.; Yang, X.; Zhong, X.; Li, C.; Tukker, A. 2021
The cell wall is considered an essential component for bacterial survival, providing structural support, and protection from environmental insults. Under normal growth conditions, filamentous... Show moreThe cell wall is considered an essential component for bacterial survival, providing structural support, and protection from environmental insults. Under normal growth conditions, filamentous actinobacteria insert new cell wall material at the hyphal tips regulated by the coordinated activity of cytoskeletal proteins and cell wall biosynthetic enzymes. Despite the importance of the cell wall, some filamentous actinobacteria can produce wall-deficient S-cells upon prolonged exposure to hyperosmotic stress. Here, we performed cryo-electron tomography and live cell imaging to further characterize S-cell extrusion in Kitasatospora viridifaciens. We show that exposure to hyperosmotic stress leads to DNA compaction, membrane and S-cell extrusion, and thinning of the cell wall at hyphal tips. Additionally, we find that the extrusion of S-cells is abolished in a cytoskeletal mutant strain that lacks the intermediate filament-like protein FilP. Furthermore, micro-aerobic culturing promotes the formation of S-cells in the wild type, but the limited oxygen still impedes S-cell formation in the ΔfilP mutant. These results demonstrate that S-cell formation is stimulated by oxygen-limiting conditions and dependent on functional cytoskeleton remodeling. Show less
Urban mining from construction and demolition waste (CDW) is highly relevant for the circular economy ambitions of the European Union (EU). Given the large volumes involved, end-of-life (EoL)... Show moreUrban mining from construction and demolition waste (CDW) is highly relevant for the circular economy ambitions of the European Union (EU). Given the large volumes involved, end-of-life (EoL) concrete is identified as one of the priority streams for CDW recycling in most EU countries, but it is currently largely downcycled or even landfilled. The European projects C2CA and VEEP have proposed several cost-effective technologies to recover EoL concrete for new concrete manufacturing. To understand the potential effects of large-scale implementation of those recycling technologies on the circular construction, this study deployed static material flow analysis (MFA) for a set of EoL concrete management scenarios in the Netherlands constructed by considering the development factors in two, technological and temporal dimensions. On the technological dimension, three treatment systems for EoL concrete management, namely: business-as-usual treatment, C2CA technological system and VEEP technological system were investigated. On the temporal dimension, 2015 was selected as the reference year, representing the current situation, and 2025 as the future year for the prospective analysis. The results show that the development of cost-effective technologies has the potential to improve the share of recycling (as opposed to downcycling) in the Netherlands from around 5% in 2015 up to 22%~32% in 2025. From the academic aspect, the presented work illustrates how the temporal dimension can be included in the static MFA study to explore the potential effects in the future. Show less
Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This... Show moreUrban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data from 867 households. Here we present that building area per household has a dilution effect on energy consumption per square meter. Neglecting this dilution effect leads to a significant overestimation of the effectiveness of building energy savings standards. Further analysis suggests that the peak of energy consumption per square meter in China's urban residential buildings occurred in 2012 when accounting for the dilution effect, which is 11 years later than it would have occurred without considering the dilution effect. Overall, overlooking the dilution effect may lead to misleading judgments of crucial energy-saving policy tools, as well as the ongoing trend of residential energy consumption in China. Show less
