Conclusion: Prevalence of mast cells in OA synovial tissue is relatively high and associates with structural damage in OA patients, suggesting a role of mast cells in this disease. (C) 2015... Show moreConclusion: Prevalence of mast cells in OA synovial tissue is relatively high and associates with structural damage in OA patients, suggesting a role of mast cells in this disease. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. Show less
Conclusion. Our data suggest that the immune cell composition of the synovium and the IFP is similar, and includes activated cells that could contribute to inflammation through secretion of... Show moreConclusion. Our data suggest that the immune cell composition of the synovium and the IFP is similar, and includes activated cells that could contribute to inflammation through secretion of proinflammatory cytokines. Moreover, preliminary analyses indicate that synovial CD4+ T cells might associate with pain in patients with endstage OA of the knee. Show less
Lange-Brokaar, B. de; Kloppenburg, M.; Andersen, S.; Dorjee, A.; Yusuf, E.; Herb-van Toorn, L.; ... ; Ioan-Facsinay, A. 2016
Conclusion: Baseline structural damage and bone turnover activity, as reflected by BMLs, seem to be involved in knee OA progression. Moreover, progression in PFJ and TFJ seems to be related. (C)... Show moreConclusion: Baseline structural damage and bone turnover activity, as reflected by BMLs, seem to be involved in knee OA progression. Moreover, progression in PFJ and TFJ seems to be related. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. Show less
Lange-Brokaar, B.J.E. de; Kloppenburg, M.; Andersen, S.; Dorjee, A.; Yusuf, E.; Toorn, L. van; ... ; Ioan-Facsinay, A. 2015
Obesity is a major risk factor of osteoarthritis development and progression. Theoretically, obesity is a factor that can be modified. While obesity epidemic is difficult to reverse because we live... Show moreObesity is a major risk factor of osteoarthritis development and progression. Theoretically, obesity is a factor that can be modified. While obesity epidemic is difficult to reverse because we live in lipogenic environment, personal approach in modify obesity may avail. Therefore, understanding how obesity leads to osteoarthritis is needed. The first three chapters of this thesis investigate several aspects of osteoarthritis: what structures are damaged, what factors are associated with worsening of osteoarthritis and how to measure worsening of osteoarthritis. The other four chapters investigate the link between obesity and osteoarthritis. We show that obesity is associated with hand osteoarthritis. Since we do not walk on our hand, there must be another factor than mechanical that cause joint damage in osteoarthritis. One of the factors is adipokines, protein produced mainly by fat tissue. We showed that adiponectin, one of the adipokines, prevents worsening of hand osteoarthritis. We concluded that obesity plays role in osteoarthritis not only due to added mechanical force but also due to added metabolic force (adipokines). These adipokines might be used as target in modifying the effect of obesity on osteoarthritis. However, we still need more studies on how obesity links with osteoarthritis Show less
OBJECTIVE To investigate the factors associated with clinical progression and good prognosis in patients with lower limb osteoarthritis (OA). METHODS Cohort study of 145 patients with OA in either... Show moreOBJECTIVE To investigate the factors associated with clinical progression and good prognosis in patients with lower limb osteoarthritis (OA). METHODS Cohort study of 145 patients with OA in either knee, hip or both. Progression was defined as 1) new joint prosthesis or 2) increase in WOMAC pain or function score during 6-years follow-up above pre-defined thresholds. Patients without progression with decrease in WOMAC pain or function score lower than pre-defined thresholds were categorized as good prognosis. Relative risks (RRs) for progression and good prognosis with 95% confidence interval (95% CI) were calculated by comparing the highest tertile or category to the lowest tertile, for baseline determinants (age, sex, BMI, WOMAC pain and function scores, pain on physical examination, total range of motion (tROM), osteophytes and joint space narrowing (JSN) scores), and for worsening in WOMAC pain and function score in 1-year. Adjustments were performed for age, sex, and BMI. RESULTS Follow-up was completed by 117 patients (81%, median age 60 years, 84% female); 62 (53%) and 31 patients (26%) showed progression and good prognosis, respectively. These following determinants were associated with progression: pain on physical examination (RR 1.2 (1.0 to 1.5)); tROM (1.4 (1.1 to 1.6); worsening in WOMAC pain (1.9 (1.2 to 2.3)); worsening in WOMAC function (2.4 (1.7 to 2.6)); osteophytes 1.5 (1.0 to 1.8); and JSN scores (2.3 (1.5 to 2.7)). Worsening in WOMAC pain (0.1 (0.1 to 0.8)) and function score (0.1 (0.1 to 0.7)), were negatively associated with good prognosis. CONCLUSION Worsening of self-reported pain and function in one year, limited tROM and higher osteophytes and JSN scores were associated with clinical progression. Worsening in WOMAC pain and function score in 1- year were associated with lower risk to have good prognosis. These findings help to inform patients with regard to their OA prognosis. Show less
Objective: To investigate in which way body mass index (BMI) and alignment affect the risk for knee osteoarthritis (OA) progression. Methods: Radiographs of 181 knees from 155 patients (85% female,... Show moreObjective: To investigate in which way body mass index (BMI) and alignment affect the risk for knee osteoarthritis (OA) progression. Methods: Radiographs of 181 knees from 155 patients (85% female, mean age 60 years) with radiographic signs of OA were analyzed at baseline and after 6 years. Progression was defined as 1-point increase in joint space narrowing score in the medial or lateral tibiofemoral (TF) compartment or having knee prosthesis during the follow-up for knees with a Kellgren and Lawrence score >= 1 at baseline. BMI at baseline was classified as normal (<25 kg/m(2)), overweight (25-30) and obese (>30). Knee alignment on baseline radiographs was categorized as normal (TF angle between 182 degrees and 184 degrees) and malalignment (<182 degrees or >184 degrees). We estimated the risk ratio (RR) with 95% confidence interval for knee OA progression for overweight and obese patients and for malaligned knees relative to normal using generalized estimating equations (GEE). Additionally, we estimated the added effect when BMI and malalignment were present together on progression of knee OA. Adjustments were made for age and sex. Results: Seventy-six knees (42%) showed progression: 27 in lateral and 66 in medial compartment. Knees from overweight and obese patients had an increased risk for progression (RR 2.4 (1.-3.6) and 2.9 (1.7-4.1), respectively). RRs of progression for malaligned, varus and valgus knee were 2.0 (1.3-2.8), 2.3 (1.4-3.1), and 1.7 (0.97-2.6), respectively. When BMI and malalignment were included in one model, the effect of overweight, obesity and malalignment did not change. The added effect when overweight and malalignment were present was 17%. Conclusion: Overweight is associated with progression of knee OA and shows a small interaction with alignment. Losing weight might be helpful in preventing the progression of knee OA. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. Show less
Objective To investigate the association between baseline serum adipokines levels-leptin, adiponectin and resistin-and long-term progression of hand osteoarthritis (HOA). Methods Baseline and 6... Show moreObjective To investigate the association between baseline serum adipokines levels-leptin, adiponectin and resistin-and long-term progression of hand osteoarthritis (HOA). Methods Baseline and 6-year radiographs of 164 patients (mean age 60 years, 81% women) with HOA (defined as a Kellgren and Lawrence score >= 2 in at least two hand joints) were assessed for joint space narrowing (JSN) in 32 hand joints using the Osteoarthritis Research Society International atlas. Progression was defined as a change in the sum of the JSN score above the smallest detectable change of 2, reflecting change above measurement error. Serum adipokines were measured at baseline and patients were categorised by adipokine tertiles. RRs (and 95% CI) of HOA progression for patients in the second and third tertiles were calculated relative to the first tertile, using generalised estimating equations. Adjustments were made for age, sex and body mass index. Results Patients in the two highest tertiles of adiponectin had a decreased risk of 70% (RR = 0.3 (0.2 to 0.7)) for HOA progression in comparison with patients in the lowest tertile. Leptin and resistin levels were not associated with progression. Conclusion Adiponectin levels are associated with progression of HOA, suggesting that adiponectin may be involved in the pathophysiology of OA. Show less
