Rapid urbanization drives massive construction, which, in return, leads to ever increasing urban metabolism challenges on the provision of raw materials, as well as the disposal of construction and... Show moreRapid urbanization drives massive construction, which, in return, leads to ever increasing urban metabolism challenges on the provision of raw materials, as well as the disposal of construction and demolition waste. Due to its large volume, the transporting and processing of these materials cause considerable greenhouse gas emissions and land use change. With this circumstance, shortening the supply chains of urban construction by efficient recycling of construction and demolition waste becomes a frontier field for the circular transition of cities. It is particularly important in current China, where the concrete recycling is still rare. This paper aims to map the opportunities and potentials of concrete recycling on the mitigation of greenhouse gas emissions and land use change, with an integrated material flow analysis and life cycle assessment for the case study city – Chongqing, China. For the baseline year 2015, four scenarios representing various recycling routes in Chongqing have been explored: (1) improving brick manufacturing; (2) recycling on-site for road base filling; (3) recycling aggregate for prefabricated concrete component and (4) recycling concrete aggregate for structure use. Results highlighted that different technological routes have different potentials to increase recycling rates but all generate co-benefits on greenhouse gases mitigation and land transformation reduction. Recycling of stony construction and demolition waste for high value concrete aggregate has the biggest potential to bring the co-benefits on greenhouse gases mitigation and land use reduction. Besides, on-site recycling for road-base aggregates also presents a high performance, especially on greenhouse gases mitigation in transport. Based on the sensitivity analysis, policy implications were discussed, highlighting the necessity of to develop the recycling routes that substitute primary gravel with aggregates recycled from the stony waste; unlocking the existing recycling capacity and restricting landfilling. Show less
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation... Show moreUlcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan(1), comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10(-5). Seven of these loci exceeded genome-wide significance (P < 5 x 10(-8)). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis. Show less
