Responding to the COVID-19 pandemic has created unprecedented social and political challenges. Mitigation strategies often disrupt the daily lives of citizens and constrain rights and privileges.... Show moreResponding to the COVID-19 pandemic has created unprecedented social and political challenges. Mitigation strategies often disrupt the daily lives of citizens and constrain rights and privileges. Policies intended to contain disease spread have provoked resentment, resistance, and backlash. We examine the extent to which specific COVID-19 policy responses influence the frequency of civil unrest. Combining insights from both grievance and opportunity models of dissent, we contend that pandemic-response policies are most likely to lead to unrest when the grievances and opportunities created by disease-mitigation strategies reinforce each other. We test our arguments with nuanced information on specific pandemic-mitigation policies, combined with geolocated events data on COVID-19-related social unrest activities. We find that policies such as workplace and school closures, which induce intense grievances and reduce the opportunity cost of engaging in collective mobilization, are associated with increases in dissent activities. Policies that restrict opportunities for mobilization, such as restrictions on public transportation, reduce the number of dissent activities. Notably, economic support policies attenuate the effects of workplace closures on dissent. Our results illustrate the varying effects of pandemic-mitigation policies on unrest depending on how the grievances they inspire relate to the opportunity they create. Show less
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for... Show moreImproved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinical or clinical tuberculosis, and for monitoring tuberculosis treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic performance significantly exceeded that of previous signatures discovered in the same cohort. Performance for diagnosing subclinical and clinical disease in HIV-uninfected and HIV-infected persons, assessed by area under the receiver-operating characteristic curve, exceeded 85%. As a screening test for tuberculosis, the sensitivity at 90% specificity met or approached the benchmarks set out in World Health Organization target product profiles for non-sputum-based tests. RISK6 scores correlated with lung immunopathology activity, measured by positron emission tomography, and tracked treatment response, demonstrating utility as treatment response biomarker, while predicting treatment failure prior to treatment initiation. Performance of the test in capillary blood samples collected by finger-prick was noninferior to venous blood collected in PAXgene tubes. These results support incorporation of RISK6 into rapid, capillary blood-based point-of-care PCR devices for prospective assessment in field studies. Show less
Globalization of supply chains has resulted in rapid increases in emission transfers from the developing to the developed world. As outsourcing has risen, developed countries have been able to... Show moreGlobalization of supply chains has resulted in rapid increases in emission transfers from the developing to the developed world. As outsourcing has risen, developed countries have been able to decarbonize domestically, at the expense of increased emissions in developing countries. However, the rapid improvement of carbon efficiency in developing regions together with the post-2008 deceleration in international trade raises the question of whether such embodied emission transfers have peaked. Here we update historical analysis, finding that emission transfers between OECD and non-OECD countries peaked in 2006, and have been declining since. The reversal is principally due to the reduction in the emissions intensity of traded goods, rather than the volume of trade. A more recent decline in embodied emissions transfers is also observed in trade between developing countries. We analyse whether these trends are likely to continue, by exploring a baseline and a Nationally Determined Contribution (NDC) scenario with the Macro-econometric Energy-Environment-Economy Model (E3ME) model. The results suggest that absolute embodied emissions will plateau at current levels or slowly return to pre-2008- crisis levels, and differences between the NDC and baseline scenarios imply that NDC policies will not result in significant carbon leakage. However, the share of national footprint embodied in imports, at least for countries with ambitious decarbonization policies, will likely increase. This suggests that, despite the world-wide stabilization of emissions transfers, addressing emissions embodied in imports will become increasingly important for reducing carbon footprints. Show less
Laugerie-Haute is one of the key sequences of the European Upper Paleolithic. However, the absolute chronologyof the sequence is not well-established, and recently the integrity of the layers has... Show moreLaugerie-Haute is one of the key sequences of the European Upper Paleolithic. However, the absolute chronologyof the sequence is not well-established, and recently the integrity of the layers has been called into question. Inthis paper, we present new radiocarbon dating results for the entire sedimentary sequence at Laugerie-HauteOuest, which contains important “Aurignacian V” and Solutrean assemblages. Our results show that the entireLaugerie-Haute Ouest sequence was deposited in a period of 8500–0,000 years, dating between 28 and19 cal. kBP. Show less
Dias Rodrigues, J.F.; Moran, D.; Wood, R.; Behrens, P.A. 2018