We invite you to join us on a walk through the newsroom of a regional newspaper, Dagblad van het Noorden. We trace how the journalists perceive, articulate, engage, embrace, challenge, are... Show moreWe invite you to join us on a walk through the newsroom of a regional newspaper, Dagblad van het Noorden. We trace how the journalists perceive, articulate, engage, embrace, challenge, are receptive to, and give form to the ‘atmospheres’ of their workspace. The concept of atmospheres is central in how we have looked at the newsroom. On this walk, we explore the spatial, socio-cultural, rhythmic, tonal, and somatic characteristics of the recently redesigned newsroom, using video, sound, text, and drawing. Employing artistic methods, we want to let you experience this newsroom together with us – giving you insight into the journalists’ lived experience of their profession as fundamentally interwoven with the idiosyncrasies of their workspace. Our host on the walk is online news editor Alfred Meester. Alfred walked us, Saskia and Sander, through the newsroom, which we visited as part of the project Exploring Journalism’s Limits (funded by the Dutch Research Council, NWO, project number: 314-99-205). Also joining us on this day is Ricky Booms, a visual artist invited to reflect on the space alongside us. Along the way, we encounter visual editors, interns, freelancers, editorial staff writers, and learn about the kinds of spaces that resonate with them. The walk takes approximately 45 minutes. Show less
Although midazolam is a frequently used sedative in neonatal intensive care units, its use in preterm neonates has been off-label. Recently, a new dosing advice for midazolam for sedation on... Show moreAlthough midazolam is a frequently used sedative in neonatal intensive care units, its use in preterm neonates has been off-label. Recently, a new dosing advice for midazolam for sedation on intensive care units has been included in the label (0.03 mg/[kg center dot h] for preterm neonates 32 weeks). Concentration-time data of a prospective multicenter study (29 patients, median gestational age 26.7 [range 24.0-31.1 weeks]) were combined with previously published data (26 patients, median gestational age 28.1 [range 26.3-33.6 weeks]), and a population pharmacokinetic model describing the maturation of midazolam pharmacokinetics was developed in NONMEM 7.3. Clearance was 73.7 mL/h for a neonate weighing 1.1 kg and changed nonlinearly with body weight (exponent 1.69). Volume of distribution increased linearly with body weight and was 1.03 L for a neonate weighing 1.1 kg. Simulations of the newly registered dosing show considerable differences in steady-state concentrations in preterm neonates. To reach similar steady-state concentrations of 400 mu g/mL (+/- 100 mu g/mL), a dose of 0.03 mg/(kg center dot h) is adequate for neonates >= 1 kg and <= 2 kg but would have to be reduced to 0.02 mg/(kg center dot h) (-33%) in neonates <1 kg and increased to 0.04 mg/(kg center dot h) (+33%) in neonates weighing >2 kg and <= 2.5 kg. The impact of the observed differences in exposure is difficult to assess because no target concentrations have yet been defined for midazolam, but the current analysis shows that one should be cautious in giving dosage advice based on historical data with a lack of reliable pharmacokinetic and effect data. Show less
Onland, W.; Cools, F.; Kroon, A.; Rademaker, K.; Merkus, M.P.; Dijk, P.H.; ... ; Data Safety Monitoring Comm 2019
