Question Urbanization has remarkable impacts on the phylogenetic and functional structures of plant communities. Both temporal and spatial comparisons along urbanization gradients are widely used... Show moreQuestion Urbanization has remarkable impacts on the phylogenetic and functional structures of plant communities. Both temporal and spatial comparisons along urbanization gradients are widely used in related studies, but there has been a lack of consistency in the results. Moreover, there is a need for studies that determine species assembly mechanisms through immigration and extinction. Therefore, two questions were addressed: (a) How do the phylogenetic and functional structures of ruderal species respond to urbanization, and do their shifts follow a similar pattern along temporal and spatial urbanization gradients? (b) What are the key underlying processes, i.e., either extinction‐ or colonization‐caused clustering, that determine the phylogenetic and functional structures of ruderal species under urbanization? Study site Two metropoles (Shanghai and Harbin) experiencing rapid urbanization in China. Methods We collected occurrence data on ruderal species from 1955 and the present in two cities. Standardized effect sizes of mean pairwise phylogenetic distance and of mean pairwise functional distance values (MPDSES and MFDSES, resp.) were calculated to test whether there was phylogenetic and/or functional structure clustering along spatial or temporal urbanization gradients. β‐MPDSES and β‐MFDSES values were used to quantify the similarities among colonists, extinct species, and residents. Results Along both the spatial and temporal gradients, the MPDSES values in each city decreased from significantly positive to significantly negative with increasing urbanization. Inconsistently, along the temporal gradients, the β‐MPDSES values of the colonists/extinct species to the residents were significantly negative; along the spatial gradients, the β‐MPDSES values of extinct species to residents were significantly positive with increasing urbanization. Conclusions We found there was a clear phylogenetic clustering of ruderal species with increasing spatial and temporal urbanization gradients. Our analysis showed that the changes across the urban–rural gradient are mainly driven by species going extinct that are phylogenetically dissimilar to the resident species. The temporal dynamics are, however, primarily driven by colonist species that are phylogenetically similar to the resident species. Show less
BACKGROUND The Shockless IMPLant Evaluation (SIMPLE) trial showed that defibrillation testing (DT) at the time of implantable cardioverter-defibrillator (ICD) implant did not improve shock efficacy... Show moreBACKGROUND The Shockless IMPLant Evaluation (SIMPLE) trial showed that defibrillation testing (DT) at the time of implantable cardioverter-defibrillator (ICD) implant did not improve shock efficacy or reduce mortality. There are no data regarding the risk of complications, including stroke, among patients with atrial fibrillation (AF) who undergo DT.OBJECTIVE The purpose of this prospectively planned substudy of SIMPLE was to evaluate the effect of DT vs no DT on clinical outcomes among patients with AF.METHODS We compared efficacy (failed appropriate shock/arrhythmic death) and safety between patients who had AF on their immediate preprocedural ECG to the rest of the study patients. Then among patients with AF we compared these outcomes between patients randomized to DT vs no DT.RESULTS Of the 2500 patients enrolled in SIMPLE, 251 (10%) were in AF immediately before ICD implant. AF patients had an increased risk of failed appropriate shock/arrhythmic death adjusted hazard ratio [HR] 1.64; 95% confidence interval [CI] 1.13-2.39; P = .009) and higher all-cause mortality (adjusted HR 1.58; 95% CI 1.2-2.08; P = .001). Among AF patients, perioperative complications and stroke did not significantly differ between DT vs no-DT groups (9.2% vs 5.4 0 /0; P = .2; and 1.7% vs 1.5%; P >.999, respectively). Failed appropriate shock or arrhythmic death occurred in 35 of 251 AF patients (14%), and the no-DT group proved not inferior to the DT group (HR 0.58; 95 0 /0 CI 0.30-1.15; P-noninferiority = .006).CONCLUSION ICD recipients with AF are at increased risk for adverse outcomes; however, DT does not improve arrhythmic survival or shock efficacy. There is no evidence that DT increased the occurrence of perioperative stroke. Show less
X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often... Show moreX-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We demonstrate that imbalanced expression of the paternal and maternal X-chromosomes is common in the general population and that the random nature of the X-inactivation mechanism can be sufficient to explain the imbalance. To this end, we analyzed blood-derived RNA and whole-genome sequencing data from 79 female children and their parents from the Genome of the Netherlands project. We calculated the median ratio of the paternal over total counts at all X-chromosomal heterozygous single-nucleotide variants with coverage ≥10. We identified two individuals where the same X-chromosome was inactivated in all cells. Imbalanced expression of the two X-chromosomes (ratios ≤0.35 or ≥0.65) was observed in nearly 50% of the population. The empirically observed skewing is explained by a theoretical model where X-inactivation takes place in an embryonic stage in which eight cells give rise to the hematopoietic compartment. Genes escaping X-inactivation are expressed from both alleles and therefore demonstrate less skewing than inactivated genes. Using this characteristic, we identified three novel escapee genes (SSR4, REPS2, and SEPT6), but did not find support for many previously reported escapee genes in blood. Our collective data suggest that skewed X-inactivation is common in the general population. This may contribute to manifestation of symptoms in carriers of recessive X-linked disorders. We recommend that X-inactivation results should not be used lightly in the interpretation of X-linked variants. Show less
In this paper, we analyze fiscal redistribution after the Great Recession. Are welfare states still effective in reducing income inequality? We use recent microdata from the Luxembourg Income Study... Show moreIn this paper, we analyze fiscal redistribution after the Great Recession. Are welfare states still effective in reducing income inequality? We use recent microdata from the Luxembourg Income Study to examine redistribution from transfers and income taxes, and the several underlying social programs that drive the changes in 31 countries. On average, we find that social transfers and income taxes reduce the Gini by 31%. In most countries, pensions are a dominant factor. After performing a number of sensitivity analyses, we conclude that the redistributive impact of the welfare state is still substantial. Show less
Vamos, M.; Healey, J.S.; Wang, J.; Connolly, S.J.; Mabo, P.; Erven, L. van; ... ; Hohnloser, S.H. 2018
In many countries the scientific funding system is shifting from an internal block funding model toward a competitive project funding model. However, there is growing concern that the competitive... Show moreIn many countries the scientific funding system is shifting from an internal block funding model toward a competitive project funding model. However, there is growing concern that the competitive project funding system favors relatively safe, conventional projects at the expense of risky, novel research. It is important to assess different funding models in order to design better funding systems for science. This paper empirically tests for differences in the novelty of funded outputs between internal block funding and competitive project funding, in the setting of Japan, where both funding models play a significant role. Combining survey data from a large sample of research projects in Japan and bibliometric information about the publications produced from these projects, we find that projects funded by competitive funds on average have higher novelty compared to those funded by internal block funds. However, such positive effects only hold for researchers with high status, such as senior and male researchers. In contrast, compared to internal block funding, competitive project funding has a negative relation to novelty for low status scientists (especially junior and female researchers). The findings suggest that the competitive project selection procedure is less receptive to novel ideas from researchers with low academic status and therefore discourages their novel research. These findings can serve as a warning about potential biases in competitive funding allocation procedures and suggest the importance of secure stable funding for allowing researchers with low status to pursue their novel ideas. Show less
Social assistance benefit schemes are a peculiar type of welfare state program. As the electoral costs are relatively low, this program forms an obvious target for cost reduction in times of... Show moreSocial assistance benefit schemes are a peculiar type of welfare state program. As the electoral costs are relatively low, this program forms an obvious target for cost reduction in times of austerity. The aim of this study is to examine the determinants of the developments in social assistance benefits. We seek to make two contributions. First, this paper provides insight into the role of economic, political, and institutional determinants of the variation in social assistance benefits. Second, cross-national data on social expenditures and income replacement rates are available for several welfare state programs, but not for social assistance benefits. Presenting minimum income benefit replacement rates, this study analyzes the developments of social assistance benefits across 26 OECD countries over the past two decades. The analysis leads to the conclusion that budgetary pressure stemming from increased exposure to international trade and soaring levels of unemployment is associated with benefit cuts. Show less
Research which explores unchartered waters has a high potential for major impact but also carries a higher uncertainty of having impact. Such explorative research is often described as taking a novel. Show moreResearch which explores unchartered waters has a high potential for major impact but also carries a higher uncertainty of having impact. Such explorative research is often described as taking a novel approach. This study examines the complex relationship between pursuing a novel approach and impact. Viewing scientific research as a combinatorial process, we measure novelty in science by examining whether a published paper makes first-time-ever combinations of referenced journals, taking into account the difficulty of making such combinations. We apply this newly developed measure of novelty to all Web of Science research articles published in 2001 across all scientific disciplines. We find that highly novel papers, defined to be those that make more (distant) new combinations, deliver high gains to science: they are more likely to be a top 1% highly cited paper in the long run, to inspire follow-on highly cited research, and to be cited in a broader set of disciplines and in disciplines that are more distant from their “home” field. At the same time, novel research is also more risky, reflected by a higher variance in its citation performance. We also find strong evidence of delayed recognition of novel papers as novel papers are less likely to be top cited when using short time-windows. In addition, we find that novel research is significantly more highly cited in “foreign” fields but not in their “home” field. Finally, novel papers are published in journals with a lower Impact Factor, compared with non-novel papers, ceteris paribus. These findings suggest that science policy, in particular funding decisions which rely on bibliometric indicators based on short-term citation counts and Journal Impact Factors, may be biased against “high risk/high gain” novel research. The findings also caution against a mono-disciplinary approach in peer review to assess the true value of novel research. Show less
Wang, J.; Caminada, K.; Goudswaard, K.P.; Wang, C. 2017
Polarization is an interesting additional social indicator for analyzing income distribution across countries, as it captures the phenomenon of ‘clustering around extreme poles’. Income... Show morePolarization is an interesting additional social indicator for analyzing income distribution across countries, as it captures the phenomenon of ‘clustering around extreme poles’. Income polarization can be closely linked to social exclusion, which is relevant for EU social policy, because combatting social exclusion is a central element of the Lisbon Agenda and the Europe 2020 Strategy. Rising income polarization has been observed outside Europe, but within the EU, polarization is relatively unexplored. This paper provides theoretical insights into this relatively new dimension of income distribution and analyzes trends in income polarization in 28 EU countries and 3 non-EU countries, using micro-data from EU-SILC over the period 2004–2012. Income polarization is rather stable over this period in European countries, and Europe-wide. It was rising among the old EU15 countries in the sub-period 2004–2008, but declining afterwards. The opposite development is witnessed for New Member States. Despite the Great Recession we find quite stable income polarization in Europe. Show less
Evergreens in science are papers that display a continual rise in annual citations without decline, at least within a sufficiently long time period. Aiming to better understand evergreens in partic... Show moreEvergreens in science are papers that display a continual rise in annual citations without decline, at least within a sufficiently long time period. Aiming to better understand evergreens in particular and patterns of citation trajectory in general, this paper develops a functional data analysis method to cluster citation trajectories of a sample of 1699 research papers published in 1980 in the American Physical Society (APS) journals. We propose a functional Poisson regression model for individual papers’ citation trajectories, and fit the model to the observed 30-year citations of individual papers by functional principal component analysis and maximum likelihood estimation. Based on the estimated paper-specific coefficients, we apply the K-means clustering algorithm to cluster papers into different groups, for uncovering general types of citation trajectories. The result demonstrates the existence of an evergreencluster of papers that do not exhibit any decline in annual citations over 30 years. Show less
