Increasing evidence indicates that evaluation of affective stimuli facilitates the execution of affect-congruent approach and avoidance responses, and vice versa. These effects are proposed to be... Show moreIncreasing evidence indicates that evaluation of affective stimuli facilitates the execution of affect-congruent approach and avoidance responses, and vice versa. These effects are proposed to be mediated by increases or decreases in the relative distance to the stimulus, due to the participant's action. In a series of experiments we investigated whether stimulus categorisation is similarly influenced when changes in this relative distance are due to movement of the stimulus instead of movements by the participant. Participants responded to happy and angry faces that appeared to approach (move towards) or withdraw (move away) from them. In line with previous findings, affective categorisation was facilitated when the movement was congruent with stimulus valence, resulting in faster and more correct responses to approaching happy and withdrawing angry faces. These findings suggest that relative distance indeed plays a crucial role in approach-avoidance congruency effects, and that these effects do not depend on the execution of movements by the participant. Show less
Oei, N.Y.L.; Tollenaar, M.S.; Elzinga, B.M.; Spinhoven, P. 2010
Noradrenalin modulates prefrontal function, such as working memory (WM), and is associated with enhanced distractibility, and enhanced memory for emotional events and stimuli. The beta-blocker... Show moreNoradrenalin modulates prefrontal function, such as working memory (WM), and is associated with enhanced distractibility, and enhanced memory for emotional events and stimuli. The beta-blocker propranolol has been shown to reduce memory for emotional stimuli. Herein we describe investigations aimed at assessing whether the administration of propranolol would reduce the interference by emotional distractions during WM performance. In a between-subjects design, 48 young, healthy men received 80 mg propranolol (n = 25) or placebo (n = 23), before performing an "emotional Sternberg task" with neutral and negatively arousing distracters. Compared to placebo, propranolol impaired WM at low load, however, it also reduced the interference by emotional distracters at high load. Furthermore, an explorative moderated-mediation analysis indicated that the observed propranolol effects on emotional distraction were partially mediated by cortisol. In future non-clinical and clinical memory studies using propranolol administration, cortisol elevations should be monitored to further investigate the potential mediating role of cortisol. (c) 2009 Elsevier Inc. All rights reserved. Show less
The main goal of the present thesis was to study the effects of stress and stress hormones on the retrieval of emotional memories in healthy humans. In addition, we were interested in the effects... Show moreThe main goal of the present thesis was to study the effects of stress and stress hormones on the retrieval of emotional memories in healthy humans. In addition, we were interested in the effects of stress hormones on post-retrieval processes like reconsolidation. That is, are there only acute and temporary effects of stress hormones on memory retrieval, or are there also long-term effects? Studying effects of stress hormones can be done in two ways; either by (experimentally) inducing stress in humans, or by exogenously administering doses of stress hormones. In the present thesis both ways were used. Furthermore, when investigating emotional memories, we can make use of memories that are created in a laboratory setting or those that derive from real life experiences, i.e. autobiographical memories. Again, both methods were investigated. We found acute stress and a single cortisol administration to have direct and long-term impairing effects on memory for neutral and emotional information that was learned and reactivated in a controlled laboratory situation. Future studies should shed more light on the generalizability of these findings to real life settings and clinical practice. Show less
Tollenaar, M.S.; Elzinga, B.M.; Spinhoven, P.; Everaerd, W. 2009
