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Southey, M.C.; Goldgar, D.E.; Winqvist, R.; Pylkas, K.; Couch, F.; Tischkowitz, M.; ... ; Tyrer, J.
2016
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
Article / Letter to editor
metadata only
Darabi, H.; Mccue, K.; Beesley, J.; Michailidou, K.; Nord, S.; Kar, S.; ... ; kConFab-AOCS Investigators
2015
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
Article / Letter to editor
metadata only
Agarwal, D.; Pineda, S.; Michailidou, K.; Herranz, J.; Pita, G.; Moreno, L.T.; ... ; TNBCC
2014
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Article / Letter to editor
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French, J.D.; Ghoussaini, M.; Edwards, S.L.; Meyer, K.B.; Michailidou, K.; Ahmed, S.; ... ; KConFab Investigators
2013
Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers
Article / Letter to editor
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Heijer, M. den; Seynaeve, C.; Timman, R.; Duivenvoorden, H.J.; Vanheusden, K.; Tilanus-Linthorst, M.; ... ; Tibben, A.
2012
Body image and psychological distress after prophylactic mastectomy and breast reconstruction in genetically predisposed women: A prospective long-term follow-up study
Article / Letter to editor
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Heijer, M. den; Seynaeve, C.; Vanheusden, K.; Timman, R.; Duivenvoorden, H.J.; Tilanus-Linthorst, M.; ... ; Tibben, A.
2012
Long-term psychological distress in women at risk for hereditary breast cancer adhering to regular surveillance: a risk profile
Article / Letter to editor
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Background: Some women at risk for hereditary breast cancer are at increased risk of psychological distress. In order to tailor support for individual women, the availability of a tool enabling the...
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Background: Some women at risk for hereditary breast cancer are at increased risk of psychological distress. In order to tailor support for individual women, the availability of a tool enabling the identification of psychologically vulnerable women at an early stage is warranted. The objectives of this study were (1) to explore long-term psychological distress in women at risk for hereditary breast cancer adhering to regular surveillance, and (2) to identify women being vulnerable for long-term psychological distress, defined in terms of a multifactorial risk profile. Methods: General distress and cancer-related distress were assessed at baseline (T0) and after 5-8 years (T1) in 197 high-risk women adhering to breast cancer surveillance. Coping styles, occurrence of breast cancer in the family of origin, breast cancer risk perception, and frequency of breast self-examination, as assessed at T0, were examined as predictor variables for long-term distress (T1). Results: Across time, women reported a significant reduction in intrusion and avoidance. Intrusion levels were increased among women who had lost a first-degree relative to breast cancer. Predictors of increased long-term distress were passive and palliative coping styles, excessive breast self-examination, and overestimation of breast cancer risk. On the other hand, coping through fostering reassuring thoughts was predictive for decreased long-term distress. Conclusion: On the basis of the identified risk profile, it is possible to identify vulnerable women at an early stage, who then may be offered additional and individually tailored support. Copyright © 2012 John Wiley & Sons, Ltd.
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Milne, R.L.; Goode, E.L.; Garca-Closas, M.; Couch, F.J.; Severi, G.; Hein, R.; ... ; AOCS Grp
2011
Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer
Article / Letter to editor
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Heijer, M. den; Vos, J.; Seynaeve, C.; Vanheusden, K.; Duivenvoorden, H.J.; Tilanus-Linthorst, M.; ... ; Tibben, A.
2010
The impact of social and personal resources on psychological distress in women at risk for hereditary breast cancer
Article / Letter to editor
metadata only
Objective: The objectives of the present study were to (1) evaluate whether social and personal resources were independently related to psychological distress and (2) examine the interrelationships...
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Objective: The objectives of the present study were to (1) evaluate whether social and personal resources were independently related to psychological distress and (2) examine the interrelationships of social and personal resources in women at risk for hereditary breast cancer.Methods: General and breast cancer specific distress, family communication regarding hereditary breast cancer, perceived social support, self-esteem, self-concept, and demographics were assessed in 222 high-risk women, having opted either for regular surveillance or prophylactic surgery.Results: Structural equation modeling showed that (1) both personal and social resources were independently associated with psychological distress and (2) the associations between social resources and psychological distress were partially mediated by personal resources. Support from family and friends was associated with a higher level of self-esteem, which in turn was associated with less general distress. Furthermore, communication regarding cancer within the nuclear family was associated with decreased feelings of stigmatization, which in turn was associated with less general and breast cancer specific distress. Moreover, open communication within the family was associated with a reduced sense of vulnerability.Conclusion: Health workers involved in the care of high-risk women should carefully monitor women's personal and social resources, and if compromised refer them for appropriate support. Copyright © 2010 John Wiley & Sons, Ltd. PMID: 21132677 [PubMed - as supplied by publisher]
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