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Leiden University Medical Center (LUMC)
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diffusion
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Ronen, I.
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Techawiboonwong, A.
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Webb, A.
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Kan, H.
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Ercan, A.E.; Techawiboonwong, A.; Versluis, M.J.; Webb, A.G.; Ronen, I.
2015
Diffusion-weighted chemical shift imaging of human brain metabolites at 7T
Article / Letter to editor
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Ronen, I.; Budde, M.; Ercan, E.; Annese, J.; Techawiboonwong, A.; Webb, A.
2014
Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology
Article / Letter to editor
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Branzoli, F.; Techawiboonwong, A.; Kan, H.; Webb, A.; Ronen, I.
2013
Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T
Article / Letter to editor
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Branzoli, F.; Techawiboonwong, A.; Kan, H.; Webb, A.; Ronen, I.
2013
Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T
Article / Letter to editor
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PURPOSE Microstructural and metabolic changes directly related to neuronal activation have been investigated using functional diffusion-weighted spectroscopy. METHODS The volume of interest was...
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PURPOSE Microstructural and metabolic changes directly related to neuronal activation have been investigated using functional diffusion-weighted spectroscopy. METHODS The volume of interest was positioned in the primary visual cortex. A time series of alternating diffusion- and non-diffusion-weighted (1) H spectra was acquired at 7 T employing stimulated echo acquisition mode sequence and a long diffusion time (Δ = 245 ms). Time-resolved series of metabolite apparent diffusion coefficient values were derived. RESULTS Significant increases in apparent diffusion coefficient of 3.3 ± 1.4% (p = 0.05) and 3.9 ± 0.9% (p = 0.002) for total n-acetyl aspartate and total creatine, respectively, and 8.1 ± 2.5% (p = 0.03) for total choline were observed in response to visual stimulation. CONCLUSION The increase in apparent diffusion coefficient for these metabolites is a potential indication for microstructural changes in neurons during neural activation and/or for an increase in the energy-dependent cytoplasmic streaming associated with enhanced metabolism during visual stimulation. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
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Kan, H.E.; Techawiboonwong, A.; Osch, M.J.P. van; Versluis, M.J.; Deelchand, D.K.; Henry, P.G.; ... ; Ronen, I.
2012
Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T
Article / Letter to editor
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Wood, E.T.; Ronen, I.; Techawiboonwong, A.; Jones, C.K.; Barker, P.B.; Calabresi, P.; ... ; Reich, D.S.
2012
Investigating Axonal Damage in Multiple Sclerosis by Diffusion Tensor Spectroscopy
Article / Letter to editor
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