This study describes the nasal system in Ecuadorian Siona, an endangered Western Tukanoan language spoken in the Ecuadorian province of Sucumbíos, using the Earbuds Method to analyze nasal events... Show moreThis study describes the nasal system in Ecuadorian Siona, an endangered Western Tukanoan language spoken in the Ecuadorian province of Sucumbíos, using the Earbuds Method to analyze nasal events acoustically. This method provides a visual representation of the timing and duration of velum gestures through intensity (dB) and amplitude (Pa) fluctuations in the nasal and oral cavities. The studied events include nasal spreading (nasal harmony), triggers, targets, blockers, and transparent segments. Meanwhile, differences between nasal phonemes and nasal allophones are also identified along with the effects of morpheme boundaries during nasal spreading events. Results reveal that, unlike many other Tukanoan languages, /m/ and /n/ function as individual phonemes independent of their oral counterparts (/p̰/ & /t̰/). In addition, nasal harmony was identified as predominantly rightward spreading apart from syllable-delimited leftward spreading to vocoid segments. Moreover, suffixes responsible for blocking nasal spreading appear to be reminiscent of oral suffixes in Eastern Tukanoan languages. Finally, more blockers were identified in Ecuadorian Siona than in most Eastern Tukanoan languages. Show less
Irvin, M.R.; Sitlani, C.M.; Floyd, J.S.; Psaty, B.M.; Bis, J.C.; Wiggins, K.L.; ... ; CHARGE Pharmacogenetics Working Gr 2019
BACKGROUNDOnly a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described.METHODSWe conducted a case-control genome-wide association study of... Show moreBACKGROUNDOnly a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described.METHODSWe conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP >= 140 mm Hg and/or diastolic BP >= 90 mm Hg) or 4 or more medication classes regardless of BP control (n(EA) = 931, n(AA) = 228). Both a normotensive control group and a treatment-responsive control group were considered in separate analyses. Normotensive controls were untreated (n(EA) = 14,210, n(AA) = 2,480) and had systolic BP/diastolic BP < 140/90 mm Hg. Treatment-responsive controls (n(EA) = 5,266, n(AA) = 1,817) had BP at goal (<140/90 mm Hg), while treated with one antihypertensive medication class. Individual cohorts used logistic regression with adjustment for age, sex, study site, and principal components for ancestry to examine the association of single-nucleotide polymorphisms with case-control status. Inverse variance-weighted fixed-effects meta-analyses were carried out using METAL.RESULTSThe known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 x 10(-8)) and in the race-combined analysis (P = 1.5 x 10(-9)) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6-0.8)). Single-nucleotide polymorphisms in this locus were robustly replicated in the Million Veterans Program (MVP) study in consideration of a treatment-responsive control group. There were no statistically significant findings for the discovery analyses including treatment-responsive controls.CONCLUSIONThis genomic discovery effort for aTRH identified CASZ1 as an aTRH risk locus. Show less
Article 28A(1)(13) of the Protocol to the Statute of the African Court of Justice and Human Rights lists ‘Illicit exploitation of natural resources’ as a criminal offence within the Court’s... Show moreArticle 28A(1)(13) of the Protocol to the Statute of the African Court of Justice and Human Rights lists ‘Illicit exploitation of natural resources’ as a criminal offence within the Court’s jurisdiction. In conjunction with the new mandate of the African Court, which includes the exercise of jurisdiction over corporations for the first time in an international treaty, the prohibition of ‘illicit exploitation of natural resources’ creates an offence with especially sharp teeth, for businesspeople, their corporations, military actors and politicians. The crime constitutes an important innovation in international law, since it offers a distinct legal basis for prosecution of a wider array of acts covered by the war crime of pillage. Nonetheless, it also comes with a set of major limitations, not the least of which is its great vagueness. This chapter offers a critical doctrinal overview of the seven sub-offences that fall within the wider banner of this new crime of Illicit Exploitation, simultaneously pointing to a range of interpretative possibilities that might accord with recent thinking about the relationship between law and resource predation. Show less
