Leiden University Scholarly Publications

Dubbink-Verheij, G.H.; Bekker, V.; Pelsma, I.C.M.; Zwet, E.W. van; Smits-Wintjens, V.E.H.J.; Steggerda, S.J.; ... ; Lopriore, E. 2017

Bloodstream infection incidence of Different central Venous catheters in neonates: a Descriptive cohort study

Article / Letter to editor

open access

Smits-Wintjens, V.E.H.J.; Rath, M.E.A.; Zwet, E.W. van; Oepkes, D.; Brand, A.; Walther, F.J.; Lopriore, E. 2013

Neonatal Morbidity after Exchange Transfusion for Red Cell Alloimmune Hemolytic Disease

Article / Letter to editor

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Rath, M.E.A.; Smits-Wintjens, V.E.H.J.; Oepkes, D.; Zwet, E.W. van; Kamp, I.L. van; Brand, A.; ... ; Lopriore, E. 2011

Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease

Article / Letter to editor

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Objective  To evaluate the incidence and severity of and risk factors for thrombocytopenia at birth in neonates with red cell alloimmunization. Study design  All neonates with haemolytic disease of... Show moreObjective  To evaluate the incidence and severity of and risk factors for thrombocytopenia at birth in neonates with red cell alloimmunization. Study design  All neonates with haemolytic disease of the foetus/newborn (HDFN) due to red cell alloimmunization admitted to our centre between January 2000 and September 2010 were included in this retrospective study. We measured platelet counts at birth and determined the incidence of thrombocytopenia (platelet count < 150 × 10(9) /l) and severe thrombocytopenia (platelet count < 50 × 10(9) /l). Risk factors for thrombocytopenia at birth were evaluated. Results  Thrombocytopenia was present in 26% (94/362) of included neonates with HDFN at birth. Severe thrombocytopenia was found in 6% (20/362) of neonates. Three risk factors were found to be independently associated with thrombocytopenia at birth: treatment with intrauterine red cell transfusion (IUT) (OR 3·32, 95% CI 1·67-6·60, P = 0·001), small for gestational age (SGA) below the 10th percentile (OR 3·32, 95% CI 1·25-8·80, P = 0·016) and lower gestational age at birth (OR 1·22/week, 95% CI 1·02-1·44, P = 0·025). Conclusions  Thrombocytopenia at birth occurs in 26% of neonates with HDFN due to red cell alloimmunization and is independently associated with IUT treatment, SGA and lower gestational age at birth. Show less