Plus-strand RNA viruses are the largest group of viruses. Many are human pathogens that inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable similarities in... Show morePlus-strand RNA viruses are the largest group of viruses. Many are human pathogens that inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable similarities in their replication. A hallmark of plus-strand RNA viruses is the remodeling of intracellular membranes to establish replication organelles (so-called “replication factories”), which provide a protected environment for the replicase complex, consisting of the viral genome and proteins necessary for viral RNA synthesis. In the current study, we investigate pan-viral similarities and virus-specific differences in the life cycle of this highly relevant group of viruses. We first measured the kinetics of viral RNA, viral protein, and infectious virus particle production of hepatitis C virus (HCV), dengue virus (DENV), and coxsackievirus B3 (CVB3) in the immuno-compromised Huh7 cell line and thus without perturbations by an intrinsic immune response. Based on these measurements, we developed a detailed mathematical model of the replication of HCV, DENV, and CVB3 and showed that only small virus-specific changes in the model were necessary to describe the in vitro dynamics of the different viruses. Our model correctly predicted virus-specific mechanisms such as host cell translation shut off and different kinetics of replication organelles. Further, our model suggests that the ability to suppress or shut down host cell mRNA translation may be a key factor for in vitro replication efficiency, which may determine acute self-limited or chronic infection. We further analyzed potential broad-spectrum antiviral treatment options in silico and found that targeting viral RNA translation, such as polyprotein cleavage and viral RNA synthesis, may be the most promising drug targets for all plus-strand RNA viruses. Moreover, we found that targeting only the formation of replicase complexes did not stop the in vitro viral replication early in infection, while inhibiting intracellular trafficking processes may even lead to amplified viral growth. Show less
Engelmann, J.B.; Dreu, C.K.W. de; Schmid, B.; Fehr, E. 2020
A growing literature at the intersection of personality psychology and behavioral economics investigates the interplay between personality and decision making in social dilemmas (1, 2). Engelmann... Show moreA growing literature at the intersection of personality psychology and behavioral economics investigates the interplay between personality and decision making in social dilemmas (1, 2). Engelmann et al. (3) extend prior research in this area by investigating the role of antisocial personality in the context of a trust game with and without punishment. Show less
How do fundamental concepts from economics, such as individuals’ preferences and beliefs, relate to equally fundamental concepts from psychology, such as relatively stable personality traits? Can... Show moreHow do fundamental concepts from economics, such as individuals’ preferences and beliefs, relate to equally fundamental concepts from psychology, such as relatively stable personality traits? Can personality traits help us better understand economic behavior across strategic contexts? We identify an antisocial personality profile and examine the role of strategic context (the “situation”), personality traits (the “person”), and their interaction on beliefs and behaviors in trust games. Antisocial individuals exhibit a specific combination of beliefs and preferences that is difficult to reconcile with a rational choice approach that assumes that beliefs about others’ behaviors are formed rationally and therefore, independently from preferences. Variations in antisocial personality are associated with effect sizes that are as large as strong variations in strategic context. Antisocial individuals have lower trust in others unless they know that they can punish them. They are also substantially less trustworthy, believe that others are like themselves, and respond to the possibility of being sanctioned more strongly, suggesting that they anticipate severe punishment if they betray their partner’s trust. Antisocial individuals are not simply acting in their economic self-interest, because they harshly punish those who do not reciprocate their trust, although that reduces their economic payoff, and they do so nonimpulsively and in a very calculated manner. Antisocial individuals honor others’ trust significantly less (if they cannot be punished) but also, harshly punish those who betray their trust. Overall, it seems that antisocial individuals have beliefs and behaviors based on a view of the world that assumes that most others are as antisocial as they themselves are. Show less
Isbell, F.; Craven, D.; Connolly, J.; Loreau, M.; Schmid, B.; Beierkuhnlein, C.; ... ; Eisenhauer, N. 2015
