Skip to main content
Leiden University
Scholarly Publications
Home
Submit
About
Select Collection
All collections
Academic speeches
Dissertations
Faculty of Archaeology
Faculty of Governance and Global Affairs
Faculty of Humanities
Faculty of Science
Faculty of Social and Behavioural Sciences
Leiden Journals, Conference Proceedings and Books
Leiden Law School
Leiden University Press
Medicine / Leiden University Medical Centre (LUMC)
Research output UL
Search box
Your Search
Enabled Filters
(-)
= Reilman, R.R.
Sort Options
Date (year)
Author / Creator
Title
Refine Results
Resource Type
Article / Letter to editor
(2)
+
-
Availability
Metadata Only
(2)
+
-
Faculty
Leiden University Medical Center (LUMC)
(2)
+
-
Collection
Medicine / Leiden University Medical Centre (LUMC)
(2)
+
-
Author
Bogaard, S.J.A. van den
(2)
+
-
Buchem, M.A. van
(2)
+
-
Craufurd, D.
(2)
+
-
Dumas, E.M.
(2)
+
-
Grond, J. van der
(2)
+
-
Hicks, S.L.
(2)
+
-
Kennard, C.
(2)
+
-
Reilman, R.R.
(2)
+
-
Roos, R.A.C.
(2)
+
-
Ruber, M.E.
(2)
+
-
Stout, J.C.
(2)
+
-
Tabrizi, S.J.
(2)
+
-
Show more
Language
en
(2)
+
-
Search results
(1 - 2 of 2)
show grid
show list
save search
Dumas, E.M.; Bogaard, S.J.A. van den; Ruber, M.E.; Reilman, R.R.; Stout, J.C.; Craufurd, D.; ... ; Roos, R.A.C.
2012
Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease
Article / Letter to editor
metadata only
Dumas, E.M.; Bogaard, S.J.A. van den; Ruber, M.E.; Reilman, R.R.; Stout, J.C.; Craufurd, D.; ... ; Roos, R.A.C.
2011
Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease
Article / Letter to editor
metadata only
Objectives: To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). Experimental design: From...
Show more
Objectives: To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). Experimental design: From the TRACK-HD study, an early stage HD group and a premanifest gene carrier group (PMGC) were age-matched to two healthy control groups; all underwent 3-T MRI scanning of the brain. Region of interest (ROI) segmentation of the corpus callosum, caudate nucleus, thalamus, prefrontal cortex, and sensorimotor cortex was applied, and the apparent fiber pathways of these regions were analyzed. Functional measures of motor, oculomotor, cognition, and behavior were correlated to DTI measures. Principle observations: In PMGC versus controls, higher apparent diffusion coefficient (ADC) was seen in white matter pathways of the sensorimotor cortex (P < 0.01) and in the ROI of corpus callosum (P < 0.017). In early HD, fiber tract analysis showed higher ADC in pathways of the corpus callosum, thalamus, sensorimotor, and prefrontal region (P < 0.01). ROI analysis showed higher diffusivity in the corpus callosum and caudate nucleus (P < 0.017). Motor, oculomotor, cognition, and probability of onset within 2 and 5 years, correlated well with ADC measures of the corpus callosum (P < 0.01 - P < 0.005), sensorimotor (P < 0.01 - P < 0.005), and prefrontal region (P < 0.01). Conclusions: Disturbances in the white matter connections of the sensorimotor cortex can be demonstrated not only in manifest HD but also in premanifest gene carriers. Connectivity measures are well related to clinical functioning. DTI measures can be regarded as a potential biomarker for HD, due to their ability to objectify changes in brain structures and their role within brain networks. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.
Show less