The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval... Show moreThe QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization. Show less
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular... Show moreThe electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N=293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease. On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci. Show less
Jiao Shao (邵郊, 1923–2017) (Fig. 1), who was an expert in physiological psychology and comparative psychology in China, made important contributions to the development of physiological psychology... Show moreJiao Shao (邵郊, 1923–2017) (Fig. 1), who was an expert in physiological psychology and comparative psychology in China, made important contributions to the development of physiological psychology and comparative psychology, scientific research and personnel training (The obituary of Jiao Shao, 2017). He was a member of the Second Discipline Review Group of the State Council (Pedagogy), the director of the third and fifth sessions of Chinese Psychological Society (CPS), the chairman of the Professional Committee on Physiological Psychology of the CPS (1984–1988), an editorial advisory board member of the Encyclopedia of China Publishing House (First Edition), an editorial board member of Acta Psychologica Sinica (1979–1991), and he was honored as a fellow of the CPS (2007). Show less
Recent years have witnessed a growing volume in Chinese interregional trade, along with the increasing disparities in environmental pressures. This has prompted an increased attention on where the... Show moreRecent years have witnessed a growing volume in Chinese interregional trade, along with the increasing disparities in environmental pressures. This has prompted an increased attention on where the responsibilities for environmental impacts should be placed. In this paper, we quantify the environmental responsibility of SO2 emissions and biodiversity impacts due to terrestrial acidification at the provincial level for the first time. We examine the environmental responsibility from the perspectives of production, consumption, and income generation by employing a Multi-Regional Input-Output (MRIO) model for 2007, 2010, and 2012. The results indicate that ~40% of SO2 emissions were driven by the consumption in provinces other than where the emissions discharged. In particular, those developed provinces were net importers of SO2 emissions and mainly outsourced their emissions to nearby developing provinces. Over the period of analysis, environmental inequality among 30 provinces was larger than GDP inequality. Furthermore, environmental inequality continued to increase while GDP inequality decreased over the time period. The results of a shared income- and consumption-based responsibility approach suggest that the environmental responsibility of SO2 emissions and biodiversity impacts for developed provinces can reach up to ~4- to 93-fold the environmental pressure occurred within those provinces. This indicates that under these accounting principles the developed northern provinces in China would bear a much larger share of the environmental responsibility. Show less
Evangelou, E.; Warren, H.R.; Mosen-Ansorena, D.; Mifsu, B.; Pazoki, R.; Gao, H.; ... ; Million Vet Program 2018
We used the virtual hand illusion paradigm to study how sense of agency and sense of (body) ownership can interact with different emotional events on stress feelings. Converging evidence for at... Show moreWe used the virtual hand illusion paradigm to study how sense of agency and sense of (body) ownership can interact with different emotional events on stress feelings. Converging evidence for at least the partial independence of agency and ownership was found. For instance, sense of agency was a better predictor of individual anxiety levels than sense of ownership and males showed stronger effects related to agency—presumably due to gender-specific attribution styles and empathy skills. Moreover, agency and ownership also interacted with emotional events and led to different anxiety levels. Taken together, our findings suggest that the disentangled sense of agency and sense of ownership can interact with different emotional events and influenced stress feelings more in threatening situations than awarding ones. Show less
