The aim of this dissertation was to explore the biological correlates of child maltreatment in a family context. We used an extended family design to investigate intergenerational transmission of... Show moreThe aim of this dissertation was to explore the biological correlates of child maltreatment in a family context. We used an extended family design to investigate intergenerational transmission of child maltreatment, the role of heritability in child maltreatment, and the association of child maltreatment with parent-childresting state connectome similarity (RScs), hair glucocorticoids, and BMI. In sum, these studies show that child maltreatment (in particular abuse) runs in families– partly because of genetic factors, partly because of environmental factors – is associated with less dyadic RScs, and higher long-term hair cortisone levels andweight. Thus, four biological systems – genetic, neural activation, endocrine, metabolic – are implicated in child maltreatment at a family level. Show less
In the current study a three-generational design was used to investigate intergenerational transmission of child maltreatment (ITCM) using multiple sources of information on child maltreatment:... Show moreIn the current study a three-generational design was used to investigate intergenerational transmission of child maltreatment (ITCM) using multiple sources of information on child maltreatment: mothers, fathers and children. A total of 395 individuals from 63 families reported on maltreatment. Principal Component Analysis (PCA) was used to combine data from mother, father and child about maltreatment that the child had experienced. This established components reflecting the convergent as well as the unique reports of father, mother and child on the occurrence of maltreatment. Next, we tested ITCM using the multi-informant approach and compared the results to those of two more common approaches: ITCM based on one reporter and ITCM based on different reporters from each generation. Results of our multi-informant approach showed that a component reflecting convergence between mother, father, and child reports explained most of the variance in experienced maltreatment. For abuse, intergenerational transmission was consistently found across approaches. In contrast, intergenerational transmission of neglect was only found using the perspective of a single reporter, indicating that transmission of neglect might be driven by reporter effects. In conclusion, the present results suggest that including multiple informants may be necessary to obtain more valid estimates of ITCM. Show less
Child-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin... Show moreChild-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin studies are mixed. In the current study, we used a cross-sectional extended family design to estimate genetic and environmental effects on experiencing child maltreatment. The sample consisted of 395 individuals (225 women; M-age = 38.85 years, range(age) = 7-88 years) from 63 families with two or three participating generations. Participants were oversampled for experienced maltreatment. Self-reported experienced child maltreatment was measured using a questionnaire assessing physical and emotional abuse, and physical and emotional neglect. All maltreatment phenotypes were partly heritable with percentages for h(2) ranging from 30% (SE = 13%) for neglect to 62% (SE = 19%) for severe physical abuse. Common environmental effects (c(2)) explained a statistically significant proportion of variance for all phenotypes except for the experience of severe physical abuse (c(2) = 9%, SE = 13%, p = .26). The genetic correlation between abuse and neglect was rho(g) = .73 (p = .02). Common environmental variance increased as socioeconomic status (SES) decreased (p = .05), but additive genetic and unique environmental variances were constant across different levels of SES. Show less
Pittner, K.; Bakermans-Kranenburg, M.J.; Alink, L.R.A.; Buisman, R.S.M.; Berg, L.J.M. van den; Block, L.H.C.G.C.C.; ... ; IJzendoorn, M.H. van 2019
Child-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin... Show moreChild-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin studies are mixed. In the current study, we used a cross-sectional extended family design to estimate genetic and environmental effects on experiencing child maltreatment. The sample consisted of 395 individuals (225 women; M-age = 38.85 years, range(age) = 7-88 years) from 63 families with two or three participating generations. Participants were oversampled for experienced maltreatment. Self-reported experienced child maltreatment was measured using a questionnaire assessing physical and emotional abuse, and physical and emotional neglect. All maltreatment phenotypes were partly heritable with percentages for h(2) ranging from 30% (SE = 13%) for neglect to 62% (SE = 19%) for severe physical abuse. Common environmental effects (c(2)) explained a statistically significant proportion of variance for all phenotypes except for the experience of severe physical abuse (c(2) = 9%, SE = 13%, p = .26). The genetic correlation between abuse and neglect was rho(g) = .73 (p = .02). Common environmental variance increased as socioeconomic status (SES) decreased (p = .05), but additive genetic and unique environmental variances were constant across different levels of SES. Show less
Child executive functions and socialization environments are crucial for the socioemotional and cognitive development of preschoolers. This study examined the role of socioeconomic status (SES),... Show moreChild executive functions and socialization environments are crucial for the socioemotional and cognitive development of preschoolers. This study examined the role of socioeconomic status (SES), ethnicity, executive functions (EFs), quality of the home environment, quantity of maternal care, and quality and quantity of professional childcare as predictors of five-year-old preschoolers' problem behavior, prosocial behavior, and language ability in 77 low-SES families with a Chilean majority or Mapuche minority background in Chile. Executive functions and the quality of the home environment were positively associated with language ability, whereas quantity of childcare was inversely related to children's language ability. All other associations were non-significant. The results corroborate the vital roles of child executive functioning and stimulating and responsive parenting in child language ability in a Latin-American context. Furthermore, our findings revealed inadequate preschool classroom quality and provide new evidence from southern Chile of the urgent need to improve the quality of Chilean children's preprimary education as a catalyst for reducing social disparities. Show less
Buisman, R.S.M.; Bakermans‐Kranenburg, M.J.; Pittner, K.; Compier, H.C.G.; Berg, L.J.M. van den; Van IJzendoorn, M.H.; ... ; Alink, L.R.A. 2019
Although childhood maltreatment has been shown to compromise adaptive parental behavior, little is known what happens in terms of physiological regulation when parents with a history of childhood... Show moreAlthough childhood maltreatment has been shown to compromise adaptive parental behavior, little is known what happens in terms of physiological regulation when parents with a history of childhood maltreatment interact with their offspring. Using a sample of 229 parents (131 women), the present study examined whether childhood maltreatment experiences are associated with parents’ behavioral and autonomic responses while resolving conflict with their offspring. Self‐reported experienced child maltreatment was measured using a questionnaire assessing abuse and neglect. Parents (Mage = 52.7 years, rangeage = 26.6–88.4 years) and their offspring (Mage = 24.6 years, rangeage = 7.5–65.6 years) participated in a videotaped parent–offspring conflict interaction task. Parental warmth, negativity, and emotional support were coded. In addition, their pre‐ejection period and respiratory sinus arrhythmia were measured as indicators of underlying sympathetic and parasympathetic nervous system reactivity, respectively. Findings demonstrated that experiences of abuse and neglect were associated with behavioral and physiological responses in different ways. Separating these two types of maltreatment in research and in clinical practice might be important. Show less
Rejection by parents is an important aspect of child maltreatment. Altered neural responses to social rejection have been observed in maltreated individuals. The current study is the first to... Show moreRejection by parents is an important aspect of child maltreatment. Altered neural responses to social rejection have been observed in maltreated individuals. The current study is the first to examine the impact of experienced and perpetrated abuse and neglect on neural responses to social exclusion by strangers versus family using a multigenerational family design, including 144 participants. The role of neural reactivity to social exclusion in the intergenerational transmission of maltreatment was also examined. Exclusion by strangers was especially associated with increased activation in the left insula, while exclusion by a family member was mainly associated with increased activation in the ACC. Neural reactivity to social exclusion by strangers in the insula, ACC and dmPFC, was associated with experienced maltreatment but not with perpetrated maltreatment. In abusive parents, altered neural reactivity during exclusion was found in other brain areas, indicating different neural correlates of experienced and perpetrated maltreatment. Hence, no mechanisms could be identified that are involved in the transmission of maltreatment. Hypersensitivity to social rejection by strangers in neglected individuals underscores the importance to distinguish between effects of abuse and neglect and suggests that the impact of experiencing rejection and maltreatment by your own parents extends beyond the family context. Show less
Buisman, R.S.M.; Pittner, K.; Compier-de Block, L.H.C.G.; Van den Berg, L.J.M.; Bakermans-Kranenburg, M.J.; Alink, L.R.A. 2018
