Leiden University Scholarly Publications

Heuvel, J.K. van den; Boon, M.R.; Hengel, I. van; Peschier-van der Put, E.; Beek, L. van; Harmelen, V. van; ... ; Meijer, O.C. 2016

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

Article / Letter to editor

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C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation. These data suggest that selective GR modulation may be a... Show moreC108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation. These data suggest that selective GR modulation may be a viable strategy for the reduction of diet-induced obesity and inflammation. Show less