Growing awareness of environmental issues and their relation to consumption patterns has givenrise to calls for sustainable consumption across the globe. In this article, we focus on the zerowaste... Show moreGrowing awareness of environmental issues and their relation to consumption patterns has givenrise to calls for sustainable consumption across the globe. In this article, we focus on the zerowaste lifestyle movement, which targets high-consumption households in the Global North as asite of change for phasing out waste in global supply chains. Our article is concerned with askinghow gender and household sustainability are mutually constituted in the zero waste lifestylemovement. We establish an analytical tension between understanding zero waste living as afurther intensification of feminised responsibility for people and the planet and as offering potentialfor transformational change – as feminised concern or feminist care. Through qualitative contentanalysis of the 10 most influential zero waste blogs globally, we show how the five zero wasterules of conduct – refuse, reduce, reuse, recycle, and rot – guide consumers towards everydayand situated engagements with waste. Organised by three cross-cutting themes – communingwith nature, organising time, and spending money – we present the normativities these rules callinto being for reconfiguring domestic activities such as cooking, cleaning, and grocery shopping. Inthe discussion, we draw out the implications of zero waste living’s emerging, contradictory gendernormativities, while recalling the political economy in which it is situated, namely a neoliberal,postfeminist landscape. We identify a continued feminisation of domestic responsibilities that isuncontested in zero waste living but also explore the progressive potential of waste-free livingto bring collective, naturecultural worlds into being as part of domestic environmental labour. Show less
Background Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of... Show moreBackground Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain. Methods We identified 113 families of MSH6 mutation carriers from five countries that we ascertained through family cancer clinics and population-based cancer registries. Mutation status, sex, age, and histories of cancer, polypectomy, and hysterectomy were sought from 3104 of their relatives. Age-specific cumulative risks for carriers and hazard ratios (HRs) for cancer risks of carriers, compared with those of the general population of the same country, were estimated by use of a modified segregation analysis with appropriate conditioning depending on ascertainment. Results For MSH6 mutation carriers, the estimated cumulative risks to ages 70 and 80 years, respectively, were as follows: for colorectal cancer, 22% (95% confidence interval [CI] = 14% to 32%) and 44% (95% CI = 28% to 62%) for men and 10% (95% CI = 5% to 17%) and 20% (95% CI = 11% to 35%) for women; for endometrial cancer, 26% (95% CI = 18% to 36%) and 44% (95% CI = 30% to 58%); and for any cancer associated with Lynch syndrome, 24% (95% CI = 16% to 37%) and 47% (95% CI = 32% to 66%) for men and 40% (95% CI = 32% to 52%) and 65% (95% CI = 53% to 78%) for women. Compared with incidence for the general population, MSH6 mutation carriers had an eightfold increased incidence of colorectal cancer (HR = 7.6, 95% CI = 5.4 to 10.8), which was independent of sex and age. Women who were MSH6 mutation carriers had a 26-fold increased incidence of endometrial cancer (HR = 25.5, 95% CI = 16.8 to 38.7) and a sixfold increased incidence of other cancers associated with Lynch syndrome (HR = 6.0, 95% CI = 3.4 to 10.7). Conclusion We have obtained precise and accurate estimates of both absolute and relative cancer risks for MSH6 mutation carriers. Show less
