RAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the... Show moreRAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the adaptive immune repertoire. We show that such VDJ with templated insertions are incidentally found in the repertoire of healthy donors. Show less
Beurskens, F.; Overdijk, M.; Strumane, K.; Buijssel, A.O.; Vermot-Desroches, C.; Kroes, T.; ... ; Breij, E. 2018
