Leiden University Scholarly Publications

Meir, H. van; Burck, I.J. du; Kam, M.L. de; Welters, M.J.P.; Burg, S.H. van der; Trimbos, J.B.M.Z.; ... ; Poelgeest, M.I.E. van 2017

The identification of patients at high risk for recurrent disease after treatment for early-stage cervical cancer

Article / Letter to editor

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Meir, H. van 2017

Immunological aspects of conventional and new treatments for cervical cancer, an immunopharmacological approach

Doctoral Thesis

open access

Conventional therapies as chemotherapy and radiotherapy impact immune populations and immune responses in cervical cancer patients. This led to new perspectives into the important role of the... Show moreConventional therapies as chemotherapy and radiotherapy impact immune populations and immune responses in cervical cancer patients. This led to new perspectives into the important role of the immune system and possibilities to optimally implement immunotherapy in the treatment of cervical cancer. Immunotherapy with HPV16-SLP vaccination is a suitable candidate for combined therapy with chemotherapy, when administered within the optimal time window, as it maximizes vaccination efficacy while tumor-induces immune suppression is tackled. To eventually improve clinical outcome in cervical cancer patients, multimodality treatment approaches need further exploration. Within that approach, the assignment of treatment dose, timing and route of administration of both immunotherapy and the classic conventional therapies are important. In addition, individualization of patients therapy based on immune markers prior to treatment should be a goal to optimize combination therapy, minimize side effects and improve clinical outcomes.  Show less

Rongen, A. van; Kervezee, L.; J.E.B. m; Meir, H. van; Hartigh, J. den; Guchelaar, H.J.; ... ; Oosterhout, F. van 2015

Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers

Other

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Meir, H. van; Kenter, G.G.; Burggraaf, J.; Kroep, J.R.; Welters, M.J.P.; Melief, C.J.M.; ... ; Poelgeest, M.I.E. van 2014

The Need for Improvement of the Treatment of Advanced and Metastatic Cervical Cancer, the Rationale for Combined Chemo-Immunotherapy

Article / Letter to editor

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Meir, H. van; Slaghekke, F.; Lopriore, E.; Wijngaarden, W.J. van 2010

Arterio-Arterial Anastomoses do not Prevent the Development of Twin Anemia-Polycythemia Sequence

Article / Letter to editor

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Monochorionic twin pregnancies are associated with increased perinatal morbidity and mortality. The vascular placental anastomoses in these pregnancies can cause severe complications We describe a... Show moreMonochorionic twin pregnancies are associated with increased perinatal morbidity and mortality. The vascular placental anastomoses in these pregnancies can cause severe complications We describe a case of twin anemia-polycythemia sequence (TAPS) with an atypical placental angioarchitecture During pregnancy serial ultrasound examinations of both twins revealed no amniotic fluid discordance and no abnormal Doppler ultrasound measurements (umbilical cord pulsatility index and middle cerebral artery peak systolic velocity). The twins, born at 33 + 3 weeks gestation after spontaneous onset of labour, were found to be anemic and polycythemic. respectively Placental examination with colored dye injection showed, apart from small ateriovenous anastomoses, an arterio-arterial anastomosis. As arterio-arterial anastomoses have not been described in cases with spontaneous TAPS to date, it was postulated that such anastomoses carried a protective effect against the development of this complication (C) 2009 Elsevier Ltd All rights reserved Show less