Purpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterialthrombotic diseases. We investigated whether these apolipoproteins have prothromboticproperties and are... Show morePurpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterialthrombotic diseases. We investigated whether these apolipoproteins have prothromboticproperties and are associated with risk of venous thromboembolism (VTE).Patients and methods: A total of 127 VTE patients and 299 controls were randomlyselected from the Multiple Environmental and Genetic Assessment of Risk Factors forVenous Thrombosis study (1999–2004), in the Netherlands. The apolipoproteins were quan-tified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuousvariable (per SD increase).Results: In controls, increases in levels of apolipoproteins were associated with increases inlevels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time.Additionally, increasing apolipoproteins C-III and E levels were associated with higherfactor VIII and von Willebrand factor levels. Levels of C-reactive protein were not associatedwith any apolipoprotein. The age- and sex-adjusted odds ratios of apolipoproteins E, C-III,CII and CI to the risk of venous thrombosis were 1.21 (95% CI, 0.98–1.49), 1.19 (95% CI,0.99–1.44), 1.24 (95% CI, 0.95–1.61) and 1.06 (95% CI, 0.87–1.30) per SD increase,respectively. These odds ratios did not attenuate after adjustments for statin use, estrogenuse, BMI, alcohol use, and self-reported diabetes.Conclusions: Levels of apolipoproteins C-I, C-II, C-III and E are associated with those ofseveral coagulation factors. However, whether these apolipoproteins are also associated withan increased risk of VTE remains to be established.Keywords: thrombosis, proteomics, lipids, cholesterol, coagulation, risk factors Show less
