Leiden University Scholarly Publications

Hoeke, G.; Nahon, K.J.; Bakker, L.E.H.; Norkauer, S.S.C.; Dinnes, D.L.M.; Kockx, M.; ... ; Rensen, P.C.N. 2017

Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans

Article / Letter to editor

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Kockx, M.; Glaros, E.; Leung, B.; Ng, T.W.; Berbee, J.F.P.; Deswaerte, V.; ... ; Kritharides, L. 2016

Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia

Article / Letter to editor

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Conclusions-We demonstrate that CsA does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA-induced hyperlipidemia, which is... Show moreConclusions-We demonstrate that CsA does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA-induced hyperlipidemia, which is associated with abnormal lipoprotein clearance, decreased lipoprotein lipase activity, and increased levels of apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9. Enhancing LDLr and lipoprotein lipase activity and decreasing apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9 levels may therefore provide attractive treatment targets for patients with hyperlipidemia receiving CsA. Show less