To ensure proper context control for archaeological samples, it is crucial that excavations determine and,where possible, follow the natural stratigraphic subdivisions in a sedimentary sequence.... Show moreTo ensure proper context control for archaeological samples, it is crucial that excavations determine and,where possible, follow the natural stratigraphic subdivisions in a sedimentary sequence. In cases with a single,unchanging source of sedimentary input, this may pose challenges. We present our strategies to deal with a>2 m deep homogeneous Pleistocene stratigraphy at Umhlatuzana rockshelter in South Africa, yieldingarchaeological remains from the Middle Stone Age. The site was originally excavated during a rescue project in 5–10 cm deep artificial spits for lack of visible stratigraphy. We revisited the shelter in 2018 and 2019. We integrate current standard practice such as piece-plotting archaeological materials with digital methods such as cluster analysis and geoarchaeological analyses (e.g., micromorphology, sedimentological analyses, geochemical analyses) to track the different sources of sedimentary input. We also develop an intensive sediment sampling strategy to illuminate geochemical variation within the sequence and postdepositional alterations affecting preservation conditions. We manage to reconstruct a natural stratigraphy of the site combining these methodologies, resulting in a radically changed understanding of the stratigraphy, depositional environment, and mechanisms of postdepositional disturbance. Show less
We develop a study protocol to efficiently and accurately identify the raw material categories constituting the lithic assemblages at Umhlatuzana rockshelter, South Africa. We combine visual and... Show moreWe develop a study protocol to efficiently and accurately identify the raw material categories constituting the lithic assemblages at Umhlatuzana rockshelter, South Africa. We combine visual and analytical methods to establish a raw material database and to provide a more accurate insight into raw material selection during the Pleistocene Middle and Later Stone Age occupational sequence of Umhlatuzana. The protocol combines petrological properties (as studied on micromorphological samples), elemental composition of the specimens (as measured with p-XRF) and visual characterization by lithic analysts. We tested the protocol by applying it to a sample of piece-plotted lithics from four spits across the stratigraphic sequence. We document the intensive use of sandstone accounting for 25% of the tested sample. We also report a larger importance of hornfels and lower proportion of quartz than was reported in previous analyses (Kaplan 1990). The combination of micromorphological and p-XRF analysis of the Umhlatuzana assemblages demonstrates that with only visual inspection, the variability of raw materials used may be misinterpreted. With accurate raw material datasets, we are better equipped to answer techno-economic questions of the southern African Stone Age. Show less
Huisman, H.; Ackermann, R.; Claes, L.M.G.F.E.; Eijck, L. van; Groot, T. de; Joosten, I.; ... ; Zhou, Z. 2023
We studied the corrosion of Roman copper alloy coins that experienced alternations or progressive changes in their burial environment. We used coins that were still embedded in soil or in a... Show moreWe studied the corrosion of Roman copper alloy coins that experienced alternations or progressive changes in their burial environment. We used coins that were still embedded in soil or in a concretion selected from three professional excataved sites - Berlicum and Krommenie in the Netherlands and Kempraten in Switserland. mCT scanning and neutron scanning were used to record the 3-D properties of these coins prior to (destructive) analyses. It proved possible to tentatively identify the coins. Microscope observations and SEM-EDX analyses revealed complex corrosion processes, related to changing burial environments. In soil horizon with fluctuating groundwater levels in a region with upwelling reducing, iron-rich groundwater, the copper in a gunmetal coin is essentially replaced by iron oxides while tin remains and forms tin-oxide bands. Fluctuating redox conditions in marine-influenced environments was shown to transform a copper-alloy coin into strongly laminated copper sulphides with embedded gypsum crystals, with an outer surface of copper and copper-iron sulphides. Burial of bronze in a charcoal rich layer probably caused temporary highly alkaline soil conditions. This caused most of the copper to leach from this coin, leaving behind a laminated tin-dominated mass, with only a limited amount of (malachite) corrosion products remaining in the surrounding groundmass. In all three cases, corrosion processes tend to be anisotropic, probably because of cold-hammering of the coins during their manufacture. Such corrosion processes on massive copper alloy coins may produce features that may lead to their incorrect classification as subferrati, i.e. copper alloy coins with an iron core. Our results may help in future to distinguish strongly corroded massive coins from subferrati. Show less
Lombardo, U.; Arroyo-Kalin, M.; Schmidt, M.; Huisman, H.; Lima, H.P.; de Paula Moraes, C.; ... ; Teixeira, W.G. 2022
Using a corpus of over 370 compositional analyses of Dutch Bronze Age and Iron Age (c. 2000 BCE AD 0) copper alloy artefacts, long-term patterns in the types of alloys used for specific bronze... Show moreUsing a corpus of over 370 compositional analyses of Dutch Bronze Age and Iron Age (c. 2000 BCE AD 0) copper alloy artefacts, long-term patterns in the types of alloys used for specific bronze objects are identified. As the Low Countries are devoid of copper ores and alloying elements, a combination of typo(chrono)logical and compositional analysis is used to identify through which European contact networks (such as Atlantic, Central European or Nordic exchange networks) these alloys were obtained. We employ a methodology that (following Bray et al., 2015) defines alloy groups by presence of As, Sb, Ag and Ni over 0.1 %wt, but expanded this classification to include Pb and to track high-impurity (>1%wt) alloys. Due to interfering soil-derived iron hydroxides, and preferent dissolution of copper from the objects’ surface, the determination of tin is in most cases overestimated when using p-XRF, so Sn was not systematically reviewed. Objects were assigned a calendar age in years BCE to facilitate chronological sorting. Using this classification, we could show how different alloys (using different base ores) were used in different periods, and in different combinations. Moreover, particular alloys were used for different groups of functional types of objects. Also, we show diachronic differences in the influx of new (or less frequently mixed) alloys and chronological trends in the substitution of As by Sn as main alloying element in the Early Bronze Age as well as the rise of leaded alloys at the close of the Bronze Age. Combining information on the composition of the objects with their typological traits, allowed us to reconstruct the scales and geographic scopes of the European contact networks in which the copper alloys used throughout later prehistory were obtained. Show less
Umhlatuzana rockshelter is an archaeological site with an occupational record covering the Middle Stone Age, Later Stone Age, and Iron Age. The presence of both Middle and Later Stone Age... Show moreUmhlatuzana rockshelter is an archaeological site with an occupational record covering the Middle Stone Age, Later Stone Age, and Iron Age. The presence of both Middle and Later Stone Age assemblages makes Umhlatuzana the ideal location for the study of the MSA–LSA transition (20–40 ka) in southern Africa. This transitional period is characterized by important modifications in stone tool technology, from prepared core technology to a toolkit based on microlith production. These changes are argued to have occurred in response to changes in climate and environment leading up to the Last Glacial Maximum. The deposits bearing the transitional assemblages at Umhlatuzana rockshelter appear homogeneous with no visible stratigraphic boundaries. This study integrates geoarchaeological techniques in order to explore fine-resolution geochemical differentiations of the sediments that are macroscopically invisible, and that will provide insight into (post-)depositional processes over time. Samples were systematically retrieved from the western profile of the site following a grid-based sampling strategy and analyzed for pH, elemental composition (XRF), and Magnetic Susceptibility. Additionally, the results were integrated with preliminary micromorphological observations. Our study reveals a steady, gradual change in the geochemistry of the deposits throughout the Pleistocene, related to a combination of environmental change and occupation intensity. We suggest that the part of the sequence reported to bear Middle to Later Stone Age transitional industries is characterized by wetter environmental conditions compared to the underlying deposits. Additionally, we support results from previous studies that excluded large scale post-depositional movement of the sedimentary sequence. Our study offers a successful multi-proxy approach to systematically sample and study archaeological deposits at the macro and micro scale, integrating a variety of geoarchaeological techniques. The approach provides insight into the depositional and post-depositional history of the site, and allows for questions of stratigraphic integrity, anthropogenic input, preservation, and environmental change to be addressed. Show less
Umhlatuzana rockshelter is an archaeological site with an occupational record covering the Middle Stone Age, Later Stone Age, and Iron Age. The presence of both Middle and Later Stone Age... Show moreUmhlatuzana rockshelter is an archaeological site with an occupational record covering the Middle Stone Age, Later Stone Age, and Iron Age. The presence of both Middle and Later Stone Age assemblages makes Umhlatuzana the ideal location for the study of the MSA-LSA transition (20-40 ka) in southern Africa. This transitional period is characterized by important modifications in stone tool technology, from prepared core technology to a toolkit based on microlith production. These changes are argued to have occurred in response to changes in climate and environment leading up to the Last Glacial Maximum. The deposits bearing the transitional assemblages at Umhlatuzana rockshelter appear homogeneous with no visible stratigraphic boundaries. This study integrates geoarchaeological techniques in order to explore fine-resolution geochemical differentiations of the sediments that are macroscopically invisible, and that will provide insight into (post-)depositional processes over time. Samples were systematically retrieved from the western profile of the site following a grid-based sampling strategy and analyzed for pH, elemental composition (XRF), and Magnetic Susceptibility. Additionally, the results were integrated with preliminary micromorphological observations. Our study reveals a steady, gradual change in the geochemistry of the deposits throughout the Pleistocene, related to a combination of environmental change and occupation intensity. We suggest that the part of the sequence reported to bear Middle to Later Stone Age transitional industries is characterized by wetter environmental conditions compared to the underlying deposits. Additionally, we support results from previous studies that excluded large scale post-depositional movement of the sedimentary sequence. Our study offers a successful multi-proxy approach to systematically sample and study archaeological deposits at the macro and micro scale, integrating a variety of geoarchaeological techniques. The approach provides insight into the depositional and post-depositional history of the site, and allows for questions of stratigraphic integrity, anthropogenic input, preservation, and environmental change to be addressed. Show less
Claes, L.M.G.F.E.; Groot, T. de; Huisman, H.; Kort, J.W. de; Os, B. van 2021
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private... Show moreProstate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is to provide high-quality evidence on prostate cancer management by unlocking the potential of big data. The project has identified critical evidence gaps in prostate cancer care, via a detailed prioritization exercise including all key stakeholders. By standardizing and integrating existing high-quality and multidisciplinary data sources from patients with prostate cancer across different stages of the disease, the resulting big data will be assembled into a single innovative data platform for research. Based on a unique set of methodologies, PIONEER aims to advance the field of prostate cancer care with a particular focus on improving prostate-cancer-related outcomes, health system efficiency by streamlining patient management, and the quality of health and social care delivered to all men with prostate cancer and their families worldwide.Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. In this Perspectives article, the authors introduce the PIONEER project and describe its aims and plans for ultimately improving prostate cancer care through the use of big data. Show less
Rationale To prevent recurrent venous thrombotic events after acute cerebral venous or dural sinus thrombosis, guidelines recommend long-term oral anticoagulation with vitamin K antagonists. Non... Show moreRationale To prevent recurrent venous thrombotic events after acute cerebral venous or dural sinus thrombosis, guidelines recommend long-term oral anticoagulation with vitamin K antagonists. Non-vitamin K oral anticoagulant experience in cerebral venous or dural sinus thrombosis is limited to case reports and series.Aim To compare dabigatran with dose-adjusted warfarin in patients with cerebral venous or dural sinus thrombosis for the prevention of recurrent venous thrombotic event.Sample size One hundred and twenty patients.Methods and design This study is a phase III, prospective, randomized, parallel-group, open-label, multicenter, exploratory trial with blinded endpoint adjudication. Patients with acute cerebral venous or dural sinus thrombosis after 5-15 days of treatment with parenteral heparin are randomized to either dabigatran etexilate 150mg twice daily or dose-adjusted (international normalized ratio 2-3) warfarin (24 weeks).Study outcome The primary endpoint is a composite of patients with new venous thrombotic event (recurring cerebral venous or dural sinus thrombosis, deep venous thrombosis of any limb, pulmonary embolism, and major bleeding (International Society on Thrombosis and Hemostasis definition)) during the treatment period. Statistics will be descriptive (number and frequencies).Study timelines Inclusion started in December 2016. Final results are expected by the end of 2018.Discussion This exploratory trial is the first to compare vitamin K with non-vitamin K antagonists in cerebral venous or dural sinus thrombosis. It will provide evidence to guide physicians and patients in choosing oral anticoagulants to prevent venous thrombotic event after acute cerebral venous or dural sinus thrombosis. ClinicalTrials.gov number: NCT02913326. Show less
Roxburgh, M.A.; Heeren, S.; Huisman, H.; Os, B. van 2018
This paper argues that portable X‐ray fluorescence spectrometry (pXRF) is a suitable elemental measurement technique to study the production of copper‐alloy artefacts. However, rather than try... Show moreThis paper argues that portable X‐ray fluorescence spectrometry (pXRF) is a suitable elemental measurement technique to study the production of copper‐alloy artefacts. However, rather than try to imitate the accuracy and precision of laboratory techniques, it is more beneficial to deploy it in a survey role, one that attempts to model chronological and geographical changes within large quantities of artefacts. To achieve this, it was investigated to what extent corrosion and the issues surrounding surface measurements affect the potential of this type of research. Analyses on early Roman period brooches gathered in the Nijmegen region of the Netherlands were subsequently compared with published data. Show less
Roxburgh, M.; Heeren, S.; Huisman, H.; Os, B. van 2017
In this article, aspects of the production and exchange of Carolingian/Ottonian disc brooches are examined through an analysis of 281 brooches selected from collections across The Netherlands. The... Show moreIn this article, aspects of the production and exchange of Carolingian/Ottonian disc brooches are examined through an analysis of 281 brooches selected from collections across The Netherlands. The composition of the brooches was measured with a Hand Held-XRF device and the results showed a sharp deviation from the alloys seen in brooches from earlier periods. The results across all geographic areas consisted of a mixture of copper, zinc and lead, but no tin. If recycling practices were present in the making of these brooches, then you might expect an element of tin to enter the mixture, as bronze items entered the alloy-recycling stream. But this appears not to be the case. This consistency rules out production by travelling merchants, or at domestic households and primitive workshops. The results suggest that production was more likely organised on a regional or even super regional scale. An analysis of production at royal estates, emporia and the great abbeys found the latter to be the most likely source of these objects. Furthermore, the Christian nature of these brooches, if produced within monastic centres, may have imbued them with religious meaning, allow for a fresh interpretation of their methods of exchange. Show less
Roxburgh, M.A.; Heeren, S.; Huisman, H.; Os, B. van 2016
We present herea compositional study ofa large number of copper-alloy broochesusing Handheld X-ray Fluorescence Spectrometry (HHpXRF). The brooches, which come fromthe area of Nijmegen, date from... Show moreWe present herea compositional study ofa large number of copper-alloy broochesusing Handheld X-ray Fluorescence Spectrometry (HHpXRF). The brooches, which come fromthe area of Nijmegen, date from the Late IronAgeuntil the 2nd c.A.D. Our aim is to explore the ways in which artefact production was organized both in the context of Roman centresand in the countryside. Show less
Rutten, M.M.E.M.; Harts-Broekhuis, A.; Quarles van Ufford, P.; Gesthuizen, T.; Haastrecht, A. van; Winther, L. de; ... ; Jong, A. de 1999