Leiden University Scholarly Publications

Your Search

Enabled Filters

  • (-) = Hofstra, R.

Search results

  • RSS Feed
(1 - 5 of 5)
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
Timofeeva, M.N.; Kinnersley ben; Farrington, S.M.; Whiffin, N.; Palles, C.; Svinti, V.; ... ; Houlston, R.S. 2015
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
Article / Letter to editor
open access
Mutations in a TGF-beta Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
Bertoli-Avella, A.M.; Gillis, E.; Morisaki, H.; Verhagen, J.M.A.; Graaf, B.M. de; Beek, G. van de; ... ; Loeys, B.L. 2015
Mutations in a TGF-beta Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
Article / Letter to editor
metadata only
The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals
Abuli, A.; Bujanda, L.; Munoz, J.; Buch, S.; Schafmayer, C.; Maiorana, M.V.; ... ; EPICOLON Consortium 2014
The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals
Article / Letter to editor
metadata only
Deciphering the Colon Cancer Genes-Report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010
Kohonen-Corish, M.R.J.; Macrae, F.; Genuardi, M.; Aretz, S.; Bapat, B.; Bernstein, I.T.; ... ; Contributors InSiGHT-HVP Workshop 2011
Deciphering the Colon Cancer Genes-Report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010
Article / Letter to editor
metadata only
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Enciso-Mora, V.; Broderick, P.; Ma, Y.; Jarrett, R.F.; Hjalgrim, H.; Hemminki, K.; ... ; Houlston, R.S. 2010
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Article / Letter to editor
metadata only
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four... Show moreTo identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 x 10(-50)). These data provide new insight into the pathogenesis of cHL. Show less