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Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis
Scally, S.W.; Law, S.C.; Ting, Y.T.; Heemst, J. van; Sokolove, J.; Deutsch, A.J.; ... ; Thomas, R. 2017
Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis
Article / Letter to editor
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Adding Ultrasound to the Treat-to-Target Strategy Shows No Benefit in Achievement of Remission: Results from the Biodam Cohort
Sepriano, A.; Ramiro, S.; Landewe, R.B.M.; Heijde, D. van der; Ohrndorf, S.; FitzGerald, O.; ... ; Maksymowych, W.P. 2017
Adding Ultrasound to the Treat-to-Target Strategy Shows No Benefit in Achievement of Remission: Results from the Biodam Cohort
Article / Letter to editor
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Are rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies linked by posttranslational modification of IgG? Comment on the article by Koppejan et al Reply
Hitchon, C.A.; Koppejan, H.; Trouw, L.A.; Huizinga, T.J.W.; Toes, R.E.M.; El-Gabalawy, H.S. 2016
Are rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies linked by posttranslational modification of IgG? Comment on the article by Koppejan et al Reply
Article / Letter to editor
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Role of Anti-Carbamylated Protein Antibodies Compared to Anti-Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First-Degree Relatives, and Healthy Controls
Koppejan, H.; Trouw, L.A.; Sokolove, J.; Lahey, L.J.; Huizinga, T.J.W.; Smolik, I.A.; ... ; Hitchon, C.A. 2016
Role of Anti-Carbamylated Protein Antibodies Compared to Anti-Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First-Degree Relatives, and Healthy Controls
Article / Letter to editor
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Heterogeneous Disease Trajectories Explain Variable Radiographic, Function and Quality of Life Outcomes in the Canadian Early Arthritis Cohort (CATCH)
Barnabe, C.; Sun, Y.; Boire, G.; Hitchon, C.A.; Haraoui, B.; Thorne, J.C.; ... ; CATCH Investigators 2015
Heterogeneous Disease Trajectories Explain Variable Radiographic, Function and Quality of Life Outcomes in the Canadian Early Arthritis Cohort (CATCH)
Article / Letter to editor
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Changes In Patient-Reported Joint Counts and Composite Indices Can Identify Flare Of Disease Activity In Recent Onset Rheumatoid Arthritis
Visser, K.; Bartlett, S.J.; Bingham, C.O.; Choy, E.; Lin, D.M.; Xiong, J.; ... ; Bykerk, V.P. 2013
Changes In Patient-Reported Joint Counts and Composite Indices Can Identify Flare Of Disease Activity In Recent Onset Rheumatoid Arthritis
Article / Letter to editor
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Reliability and Validity Of Patient-Reported Joint Counts and Determinants Of Disagreement With The Physician In Recent Onset Rheumatoid Arthritis
Visser, K.; Pope, J.E.; Choy, E.; Bingham, C.O.; Bartlett, S.J.; Boire, G.; ... ; Bykerk, V.P. 2013
Reliability and Validity Of Patient-Reported Joint Counts and Determinants Of Disagreement With The Physician In Recent Onset Rheumatoid Arthritis
Article / Letter to editor
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Responsiveness Of The Outcomes Measures In Rheumatology Clinical Trials Initiative's Preliminary Flare Questions To Detect Flares Within Patients In The Canadian Early Arthritis Cohort
Bykerk, V.P.; Visser, K.; Choy, E.; Bingham, C.O.; Lin, D.M.; Xiong, J.; ... ; OMERACT Flare Working Grp 2013
Responsiveness Of The Outcomes Measures In Rheumatology Clinical Trials Initiative's Preliminary Flare Questions To Detect Flares Within Patients In The Canadian Early Arthritis Cohort
Article / Letter to editor
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Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives
Hitchon, C.A.; Chandad, F.; Ferucci, E.D.; Willemze, A.; Ioan-Facsinay, A.; Woude, D. van der; ... ; El-Gabalawy, H.S. 2010
Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives
Article / Letter to editor
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Objective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a role in... Show moreObjective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a role in breaking immune tolerance to citrullinated antigens. We studied a cohort of patients with RA and their relatives looking for associations between anti-P. gingivalis antibodies and ACPA. Methods. Patients with RA (n = 82) and their relatives (n = 205) from a North American Native (NAN) population were studied, along with 47 NAN and 60 non-NAN controls. IgM and IgA rheumatoid factor (RF) were tested by nephelometry and ELISA. Second-generation anticyclic citrullinatal peptide (anti-CCP2) isotypes and IgG anti-P. gingivalis lipopolysaccharides were tested by ELISA. HLA-DRB1 typing was performed by sequencing. Oral hygiene and smoking habits were assessed by questionnaires. Results. Autoantibody frequency in patients with RA and relatives: ACPA 91% vs 19%, respectively; IgM RF 82% vs 17%; IgA RF 48% vs 22%. Anti-P. gingivalis levels were higher in patients with RA compared to relatives and controls (p = 0.005) and higher in ACPA-positive patients with RA than in ACPA-negative patients with RA (p = 0.04) and relatives (p < 0.001), but comparable in RF-positive and RF-negative patients and relatives. Poor oral hygiene and smoking were prevalent, but with no clear association with autoantibodies. Relatives with 2 shared-epitope alleles were more likely to be ACPA-positive (OR 2.5, p = 0.02). Conclusion. In a genetically predisposed population of NAN patients with RA and their relatives, anti-P. gingivalis antibodies were associated with ACPA. These findings suggest that immune responses to P. gingivalis may be involved in breaking immune tolerance to citrullinated antigens. (First Release May 1 2010; J Rheumatol 2010;37:1105-12; doi:10.3899/jrheum.091323) Show less