Leiden University Scholarly Publications

Beek, L. van; Vroegrijk, I.O.C.M.; Katiraei, S.; Heemskerk, M.M.; Dam, A.D. van; Kooijman, S.; ... ; Harmelen, V. van 2015

FcR gamma-Chain Deficiency Reduces the Development of Diet-Induced Obesity

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Kooijman, S.; Meurs, I.; Beek, L. van; Khedoe, P.P.S.J.; Giezekamp, A.; Pike-Overzet, K.; ... ; Rensen, P.C.N. 2015

Splenic autonomic denervation increases inflammatory status but does not aggravate atherosclerotic lesion development

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Beek, L. van; Klinken, J.B. van; Pronk, A.C.M.; Dam, A.D. van; Dirven, E.; Rensen, P.C.N.; ... ; Harmelen, V. van 2015

The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice

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Boon, M.R.; Bakker, L.E.H.; Haks, M.C.; Quinten, E.; Schaart, G.; Beek, L. van; ... ; Rensen, P.C.N. 2015

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

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Lips, M.A.; Klinken, J.B. van; Harmelen, V. van; Dharuri, H.K.; Hoen, P.A.C. 't; Laros, J.F.J.; ... ; Dijk, K.W. van 2014

Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes

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Lips, M.A.; Klinken, J.B. van; Harmelen, V. van; Dharuri, H.K.; Hoen, P.A. 't; Laros, J.F.; ... ; Willems van Dijk, K. 2014

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes

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OBJECTIVE\nObesity and type 2 diabetes mellitus (T2DM) have been associated with increased levels of circulating branched-chain amino acids (BCAAs) that may be involved in the pathogenesis of... Show moreOBJECTIVE\nObesity and type 2 diabetes mellitus (T2DM) have been associated with increased levels of circulating branched-chain amino acids (BCAAs) that may be involved in the pathogenesis of insulin resistance. However, weight loss has not been consistently associated with the reduction of BCAA levels.\nRESEARCH DESIGN AND METHODS\nWe included 30 obese normal glucose-tolerant (NGT) subjects, 32 obese subjects with T2DM, and 12 lean female subjects. Obese subjects underwent either a restrictive procedure (gastric banding [GB], a very low-calorie diet [VLCD]), or a restrictive/bypass procedure (Roux-en-Y gastric bypass [RYGB] surgery). Fasting blood samples were taken for the determination of amine group containing metabolites 4 weeks before, as well as 3 weeks and 3 months after the intervention.\nRESULTS\nBCAA levels were higher in T2DM subjects, but not in NGT subjects, compared with lean subjects. Principal component (PC) analysis revealed a concise PC consisting of all BCAAs, which showed a correlation with measures of insulin sensitivity and glucose tolerance. Only after the RYGB procedure, and at both 3 weeks and 3 months, were circulating BCAA levels reduced.\nCONCLUSIONS\nOur data confirm an association between deregulation of BCAA metabolism in plasma and insulin resistance and glucose intolerance. Three weeks after undergoing RYGB surgery, a significant decrease in BCAAs in both NGT as well as T2DM subjects was observed. After 3 months, despite inducing significant weight loss, neither GB nor VLCD induced a reduction in BCAA levels. Our results indicate that the bypass procedure of RYGB surgery, independent of weight loss or the presence of T2DM, reduces BCAA levels in obese subjects. Show less

Bouazzaoui, F. el; Henneman, P.; Thijssen, P.; Visser, A.; Koning, F.; Lips, M.A.; ... ; Harmelen, V. van 2014

Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women

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Beek, L. van; Lips, M.A.; Visser, A.; Pijl, H.; Ioan-Facsinay, A.; Toes, R.; ... ; Harmelen, V. van 2014

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance

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Ioan-Facsinay, A.; Kwekkeboom, J.C.; Westhoff, S.; Giera, M.; Rombouts, Y.; Harmelen, V. van; ... ; Toes, R.E.M. 2013

Adipocyte-derived lipids modulate CD4(+) T-cell function

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