ObjectiveTo understand mental healthcare professionals’ and clients’ needs and preferences regarding smoking cessation care in mental healthcare settings.MethodIndividual semi-structured interviews... Show moreObjectiveTo understand mental healthcare professionals’ and clients’ needs and preferences regarding smoking cessation care in mental healthcare settings.MethodIndividual semi-structured interviews conducted in the Netherlands between March and July 2021, with 18 mental healthcare professionals and 16 people with a DSM 5 diagnosis who smoked. Qualitative analysis followed the framework approach.ResultsBoth professionals and clients reported that successful smoking cessation would benefit client’s health, but was difficult to achieve. There were different views on who was responsible for smoking cessation care. Clients do not often initiate or bring up smoking cessation, although they often want to quit smoking to improve their overall (mental) health. Most clients stressed the need for support in quitting smoking, provided by an active, experienced professional who takes the initiative to discuss cessation. Conversely, professionals indicated that they rarely initiate this discussion, because they believe that clients should decide the focus of treatment, and that addressing smoking cessation may harm the therapeutic relationship. Professionals perceived clients as carrying the ultimate responsibility for smoking cessation.DiscussionProfessionals and clients agree that smoking cessation care should be tailored to the client’s needs. However, as both clients and professionals wait for the other party to initiate a discussion about cessation, the issue often remains unaddressed. To increase chances of successful smoking cessation, clearly defined responsibilities regarding initiation and provision of smoking cessation care are required. Show less
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple... Show moreWe evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic associations across 49 different tissues of 78.3% and 62.4% between plasma proteins and gene expression. We represent the genetic and molecular associations in networks including 2828 known GWAS variants, showing that GWAS variants are more often connected to gene expression in trans than other molecular phenotypes in the network. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants using different molecular phenotypes in an accessible tissue. Show less
