Background: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic... Show moreBackground: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic therapy at the end of life is rare in practice. It is often continued until death, possibly resulting in excess bleeding, an increased disease burden and higher healthcare costs.Methods: The SERENITY consortium comprises researchers and clinicians from eight European countries with specialties in different clinical fields, epidemiology and psychology. SERENITY will use a comprehensive approach combining a realist review, flash mob research, epidemiological studies, and qualitative interviews. The results of these studies will be used in a Delphi process to reach a consensus on the optimal design of the shared decision support tool. Next, the shared decision support tool will be tested in a randomised controlled trial. A targeted implementation and dissemination plan will be developed to enable the use of the SERENITY tool across Europe, as well as its incorporation in clinical guidelines and policies. The entire project is funded by Horizon Europe.Results: SERENITY will develop an information-driven shared decision support tool that will facilitate treatment decisions regarding the appropriate use of antithrombotic therapy in people with cancer at the end of life.Conclusions: We aim to develop an intervention that guides the appropriate use of antithrombotic therapy, prevents bleeding complications, and saves healthcare costs. Hopefully, usage of the tool leads to enhanced empowerment and improved quality of life and treatment satisfaction of people with advanced cancer and their care givers. Show less
The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby... Show moreThe Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class Show less
Although English is becoming increasingly entrenched in Western Europe, large‐scale comparative studies of attitudes among the general public to this development are scarce. We investigate over 4... Show moreAlthough English is becoming increasingly entrenched in Western Europe, large‐scale comparative studies of attitudes among the general public to this development are scarce. We investigate over 4,000 Dutch and Germans’ attitudes towards English based on responses to an attitudinal questionnaire. Respondents saw English as a useful additional language, but not generally as a threat to their national language. Using k‐means, an unsupervised clustering algorithm, we identified two attitudinal groups per country. Respondents with positive attitudes towards English, regardless of nationality, tended to be younger, urban, better educated and more proficient in English than their compatriots with more negative views of English. These within‐country differences outweighed between‐country ones, for example, that Germans were more confident in the status of their L1, whereas Dutch showed signs of ‘English fatigue’. The findings thus appear to confirm the previously identified divide between elite ‘haves’ versus ‘have‐nots’ of English. Show less
It is presumed in the Policing European Metropolises Project (PEMP) that the metropolitan area is an increasingly important object of policing governance, given the transnational challenges... Show moreIt is presumed in the Policing European Metropolises Project (PEMP) that the metropolitan area is an increasingly important object of policing governance, given the transnational challenges encountered by European nation states, including the movement of capital, labour, goods and services enabled by the Treaty on European Union: the ‘Amsterdam Settlement’. In this sense, metropolitan policing is, in part, an artefact of the Amsterdam Settlement and the four freedoms which facilitate mobility across national territories and, in doing so, create new internal security fields. This is a principal insight of the concept of multiple, overlapping, internal security fields introduced in Chapter One of this collection. Illicit, as well as licit, capital, labour, goods and services move from particular localities to others and, especially, to the metropolises in which the markets for these are concentrated. This can be understood as a specific European instance of the broader process of ‘glocalisation’, a concept coined by social scientists to characterise greater transnational mobility and how this privileges certain localities that are able to project their political, economic and cultural power, acting as ‘command points’ (Sassen, 2001; Massey, 2007) in emerging global markets, whilst subordinating those localities that struggle to adapt to these global forces (Swyngedouw, 1997). The basic assumption behind the PEMP is that this process is producing a significant and uneven development of security problems and responses that need to be registered at the level of the metropolis, given that city-regions have different trajectories in the import and export of security problems. Contributors to this edited collection were invited to reflect on the particular significance of metropolitan policing in different nation-state contexts, as registered through reference to particular governing arrangements and policy agendas, in order to test and to adapt this proposition (see Chapter One, this volume). Show less
Elwyn, G.; Lloyd, A.; May, C.; Weijden, T. van der; Stiggelbout, A.; Edwards, A.; ... ; Epstein, R. 2014
