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(1 - 12 of 12)
TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I-low cancers
Marijt, K.A.; Doorduijn, E.M.; Hall, T. van 2019
TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I-low cancers
Article / Letter to editor
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T cells specific for a TAP-independent self-peptide remain naive in tumor-bearing mice and are fully exploitable for therapy
Doorduijn, E.M.; Sluijter, M.; Marijt, K.A.; Querido, B.J.; Burg, S.H. van der; Hall, T. van 2018
T cells specific for a TAP-independent self-peptide remain naive in tumor-bearing mice and are fully exploitable for therapy
Article / Letter to editor
open access
T cells engaging the conserved Mhc class ib Molecule Qa-1(b) with TaP-independent Peptides are semi-invariant lymphocytes
Doorduijn, E.M.; Sluijter, M.; Querido, B.J.; Seidel, U.J.E.; Oliveira, C.C.; Burg, S.H. van der; Hall, T. van 2018
T cells engaging the conserved Mhc class ib Molecule Qa-1(b) with TaP-independent Peptides are semi-invariant lymphocytes
Article / Letter to editor
open access
Vaccination with proline-substituted neoepitope Trh4 generates enhanced CTL responses against tumors
Hafstrand, I.; Doorduijn, E.M.; Duru, A.D.; Sun, R.; Talyzina, A.; Sluijter, M.; ... ; Achour, A. 2017
Vaccination with proline-substituted neoepitope Trh4 generates enhanced CTL responses against tumors
Article / Letter to editor
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CD4(+) T Cell and NK Cell Interplay Key to Regression of MHC Class I-low Tumors upon TLR7/8 Agonist Therapy
Doorduijn, E.M.; Sluijter, M.; Salvatori, D.C.; Silvestri, S.; Maas, S.; Arens, R.; ... ; Hall, T. van 2017
CD4(+) T Cell and NK Cell Interplay Key to Regression of MHC Class I-low Tumors upon TLR7/8 Agonist Therapy
Article / Letter to editor
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T cell immunity against MHC-Ilow tumors in mouse models
Doorduijn, E.M. 2017
T cell immunity against MHC-Ilow tumors in mouse models
Doctoral Thesis
open access
2018-12-29T00:00:00Z; 2018-12-29T00:00:00Z; 2018-12-29T00:00:00Z
Tumors can evade recognition by the immune system through downregulation of the peptide-presenting MHC-I molecules. In this thesis, we describe that these tumors can still be targeted by a... Show moreTumors can evade recognition by the immune system through downregulation of the peptide-presenting MHC-I molecules. In this thesis, we describe that these tumors can still be targeted by a novel category of CD8 T cells, recognizing a specific peptide presented on those immune-escaped tumors. We describe the selection and characteristics of these specific T cells and show they can protect against a challenge with these MHC-I low tumors. This could be a novel type of therapy for tumors which have become resistant against conventional (immune)therapies.   Show less
The urgent need to recover MHC class I in cancers for effective immunotherapy
Garrido, F.; Aptsiauri, N.; Doorduijn, E.M.; Lora, A.M.G.; Hall, T. van 2016
The urgent need to recover MHC class I in cancers for effective immunotherapy
Article / Letter to editor
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The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer
Hafstrand, I.; Doorduijn, E.M.; Duru, A.D.; Buratto, J.; Oliveira, C.C.; Sandalova, T.; ... ; Achour, A. 2016
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer
Article / Letter to editor
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TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
Doorduijn, E.M.; Sluijter, M.; Querido, B.J.; Oliveira, C.C.; Achour, A.; Ossendorp, F.; ... ; Hall, T. van 2016
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
Article / Letter to editor
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Limited Density of an Antigen Presented by RMA-S Cells Requires B7-1/CD28 Signaling to Enhance T-Cell Immunity at the Effector Phase
Li, X.L.; Sluijter, M.; Doorduijn, E.M.; Kale, S.P.; McFerrin, H.; Liu, Y.Y.; ... ; Zhang, Q.J. 2014
Limited Density of an Antigen Presented by RMA-S Cells Requires B7-1/CD28 Signaling to Enhance T-Cell Immunity at the Effector Phase
Article / Letter to editor
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The Thirteenth International Conference on Progress in Vaccination Against Cancer (PIVAC-13), October 2-4, 2013, Amsterdam, The Netherlands: the current standing of anti-tumor immunotherapeutic approaches
Melief, S.M.; Visconti, V.V.; Doorduijn, E.M.; Santegoets, S.J.A.M. 2014
The Thirteenth International Conference on Progress in Vaccination Against Cancer (PIVAC-13), October 2-4, 2013, Amsterdam, The Netherlands: the current standing of anti-tumor immunotherapeutic approaches
Article / Letter to editor
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Tumor-infiltrating CD14-positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma
Steenwijk, P.J.D. van; Ramwadhdoebe, T.H.; Goedemans, R.; Doorduijn, E.M.; Ham, J.J. van; Gorter, A.; ... ; Jordanova, E.S. 2013
Tumor-infiltrating CD14-positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma
Article / Letter to editor
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