Leiden University Scholarly Publications

Locke, A.E.; Kahali, B.; Berndt, S.I.; Justice, A.E.; Pers, T.H.; Felix, R.; ... ; Erdmann, J. 2015

Genetic studies of body mass index yield new insights for obesity biology

Article / Letter to editor

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Chambers, J.C.; Zhang, W.H.; Lord, G.M.; Harst, P. van der; Lawlor, D.A.; Sehmi, J.S.; ... ; Kooner, J.S. 2010

Genetic loci influencing kidney function and chronic kidney disease

Article / Letter to editor

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Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these,... Show moreUsing genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. Show less