CO is an important component of a protoplanetary disc as it is one of the most abundant gas phase species. Furthermore, observations of CO transitions can be used as a diagnostic of the gas,... Show moreCO is an important component of a protoplanetary disc as it is one of the most abundant gas phase species. Furthermore, observations of CO transitions can be used as a diagnostic of the gas, tracing conditions in both the inner and outer disc. We present Herschel/PACS spectroscopy of a sample of 22 Herbig Ae/Be (HAEBEs) and eight T Tauri stars (TTS), covering the pure rotational CO transitions from J = 14 { arr} 13 up to J = 49 { arr} 48. CO is detected in only five HAEBEs, namely AB Aur, HD 36112, HD 97048, HD 100546, and IRS 48, and in four TTS, namely AS 205, S CrA, RU Lup, and DG Tau. The highest transition detected is J = 36 { arr} 35 with E$_{up}$ of 3669 K, seen in HD 100546 and DG Tau. We construct rotational diagrams for the discs with at least three CO detections to derive T$_{rot}$ and find average temperatures of 270 K for the HAEBEs and 485 K for the TTS. The HD 100546 star requires an extra temperature component at T$_{rot}$ ~{} 900-1000 K, suggesting a range of temperatures in its disc atmosphere, which is consistent with thermo-chemical disc models. In HAEBEs, the objects with CO detections all have flared discs in which the gas and dust are thermally decoupled. We use a small model grid to analyse our observations and find that an increased amount of flaring means higher line flux, as it increases the mass in warm gas. CO is not detected in our flat discs as the emission is below the detection limit. We find that HAEBE sources with CO detections have high L$_{UV}$ and strong PAH emission, which is again connected to the heating of the gas. In TTS, the objects with CO detections are all sources with evidence of a disc wind or outflow. For both groups of objects, sources with CO detections generally have high UV luminosity (either stellar in HAEBEs or due to accretion in TTS), but this is not a sufficient condition for the detection of the far-IR CO lines. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Appendices are available in electronic form at http://www.aanda.orgShow less
Grady, C.; Muto, T.; Hashimoto, J.; Fukagawa, M.; Currie, T.; Biller, B.; ... ; Tamura, M. 2013
We present the first near-IR scattered light detection of the transitional disk associated with the Herbig Ae star MWC 758 using data obtained as part of the Strategic Exploration of Exoplanets... Show moreWe present the first near-IR scattered light detection of the transitional disk associated with the Herbig Ae star MWC 758 using data obtained as part of the Strategic Exploration of Exoplanets and Disks with Subaru, and 1.1 {$μ$}m Hubble Space Telescope/NICMOS data. While submillimeter studies suggested there is a dust-depleted cavity with r = 0.''35, we find scattered light as close as 0.''1 (20-28 AU) from the star, with no visible cavity at H, K', or K$_s$ . We find two small-scaled spiral structures that asymmetrically shadow the outer disk. We model one of the spirals using spiral density wave theory, and derive a disk aspect ratio of h ~{} 0.18, indicating a dynamically warm disk. If the spiral pattern is excited by a perturber, we estimate its mass to be 5$^{+3}$ $_{- 4}$ M$_J$ , in the range where planet filtration models predict accretion continuing onto the star. Using a combination of non-redundant aperture masking data at L' and angular differential imaging with Locally Optimized Combination of Images at K' and K$_s$ , we exclude stellar or massive brown dwarf companions within 300 mas of the Herbig Ae star, and all but planetary mass companions exterior to 0.''5. We reach 5{$σ$} contrasts limiting companions to planetary masses, 3-4 M$_J$ at 1.''0 and 2 M$_J$ at 1.''55, using the COND models. Collectively, these data strengthen the case for MWC 758 already being a young planetary system. Show less
We present Herschel-HIFI, SPIRE, and PACS 50-670 {$μ$}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722)... Show moreWe present Herschel-HIFI, SPIRE, and PACS 50-670 {$μ$}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the ''FOOSH'' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L $_{bol}$, T $_{bol}$, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of $^{13}$CO (J $_{up}$ of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 { arr} 22 and evidence for H$_{2}$O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for ''cool'' CO components range from 20 to 81 K, for ~{} 10$^{50}$ total CO molecules. We detect [C I] and [N II] primarily as diffuse emission. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA. Show less
Grady, C.; Muto, T.; Hashimoto, J.; Fukagawa, M.; Currie, T.; Biller, B.; ... ; Tamura, M. 2013
We present the first near-IR scattered light detection of the transitional disk associated with the Herbig Ae star MWC 758 using data obtained as part of the Strategic Exploration of Exoplanets and... Show moreWe present the first near-IR scattered light detection of the transitional disk associated with the Herbig Ae star MWC 758 using data obtained as part of the Strategic Exploration of Exoplanets and Disks with Subaru, and 1.1 {$μ$}m Hubble Space Telescope/NICMOS data. While submillimeter studies suggested there is a dust-depleted cavity with r = 0.''35, we find scattered light as close as 0.''1 (20-28 AU) from the star, with no visible cavity at H, K', or K$_s$ . We find two small-scaled spiral structures that asymmetrically shadow the outer disk. We model one of the spirals using spiral density wave theory, and derive a disk aspect ratio of h ~{} 0.18, indicating a dynamically warm disk. If the spiral pattern is excited by a perturber, we estimate its mass to be 5$^{+3}$ $_{- 4}$ M$_J$ , in the range where planet filtration models predict accretion continuing onto the star. Using a combination of non-redundant aperture masking data at L' and angular differential imaging with Locally Optimized Combination of Images at K' and K$_s$ , we exclude stellar or massive brown dwarf companions within 300 mas of the Herbig Ae star, and all but planetary mass companions exterior to 0.''5. We reach 5{$σ$} contrasts limiting companions to planetary masses, 3-4 M$_J$ at 1.''0 and 2 M$_J$ at 1.''55, using the COND models. Collectively, these data strengthen the case for MWC 758 already being a young planetary system. Show less
Wei, H.; Hu, C.X.; Wang, M.; Hoek, A.M. van den; Reijmers, T.H.; Wopereis, S.; ... ; Greef, J. van der 2012
BACKGROUND: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which... Show moreBACKGROUND: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. METHODOLOGY/PRINCIPAL FINDINGS: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p<0.001), CETP levels (-31%, p<0.001), CETP activity (-74%, p<0.001) and increased HDL-C (39%, p<0.05). It influenced lipidomics classes of cholesterol esters and triglycerides the most. Rimonabant induced a weight loss (-9%, p<0.05), but only a moderate improvement of lipid profiles. In vitro, SUB885C extract caused adipolysis stimulation and adipogenesis inhibition in 3T3-L1 cells. CONCLUSIONS: SUB885C, a multi-components preparation, is able to produce anti-atherogenic changes in lipids of the ApoE*3Leiden.CETP mice, which are comparable to those obtained with compounds belonging to known drugs (e.g. rimonabant, atorvastatin, niacin). This study successfully illustrated the power of lipidomics in unraveling intervention effects and to help finding new targets or ingredients for lifestyle-related metabolic abnormality Show less
Hu, C.X.; Wei, H.; Hoek, A.M. van den; Wang, M.; Heijden, R. van der; Spijksma, G.; ... ; Greef, J. van der 2011
Mid-infrared (mid-IR) astronomical observations show that molecules freeze out on interstellar grains to form interstellar ices. These ices play an important role in the chemical evolution of... Show moreMid-infrared (mid-IR) astronomical observations show that molecules freeze out on interstellar grains to form interstellar ices. These ices play an important role in the chemical evolution of molecules in space. Understanding the physical interactions and chemical reactions that take place in these ices gives us important clues to how the ices are formed and which role they play in the formation of complex molecules. The physical interactions in H2O:CO binary ices and in CH3OH and NH3 containing ices are studied both in the laboratory and in space by means of mid-IR spectroscopy, resulting in the unambiguous detection of NH3 in a low-mass protostar. Additionally, mid-IR and near-UV/VIS spectroscopic measurements on the ultraviolet induced photochemistry of large molecules, Polycyclic Aromatic Hydrocarbons (PAHs), trapped in ices are described. These molecules are known to be abundantly present in space, but their influence on the chemical evolution of interstellar ices has never been studied in detail. The experiments indicate that the processes are important in the formation of complex and charged molecules and that new astrochemical models should take the role of PAHs in ice into account. Show less
