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(1 - 10 of 10)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, A.E.; Winkler, T.W.; Feitosa, M.F.; Graff, M.; Fisher, V.A.; Young, K.; ... ; Qi, L. 2017
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Article / Letter to editor
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Blood RNA expression profiles undergo major changes during the seventh decade
Gheorghe, M.; Schurmann, C.; Peters, M.J.; Uitterlinden, A.G.; Hofman, A.; Biffar, R.; ... ; Raz, V. 2016
Blood RNA expression profiles undergo major changes during the seventh decade
Article / Letter to editor
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, C.; Teumer, A.; Gorski, M.; Chu, A.Y.; Li, M.; Mijatovic, V.; ... ; ECHOGen Consortium 2016
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Article / Letter to editor
metadata only
No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects
Baumert, J.; Huang, J.; McKnight, B.; Sabater-Lleal, M.; Steri, M.; Chu, A.Y.; ... ; Smith, N.L. 2014
No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects
Article / Letter to editor
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Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, A.R.; Esko, T.; Yang, J.; Vedantam, S.; Pers, T.H.; Gustafsson, S.; ... ; Kastelei 2014
Defining the role of common variation in the genomic and biological architecture of adult human height
Article / Letter to editor
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Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
Parsa, A.; Fuchsberger, C.; Kottgen, A.; O'Seaghdha, C.M.; Pattaro, C.; Andrade, M. de; ... ; Boeger, C.A. 2013
Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
Article / Letter to editor
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Chasman, D.I.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, C.A.; Endlich, K.; ... ; WTCCC2 2012
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Article / Letter to editor
metadata only
Genome-wide meta-analysis of common variant differences between men and women
Boraska, V.; Jeroncic, A.; Colonna, V.; Southam, L.; Nyholt, D.R.; Rayner, N.W.; ... ; Wellcome Trust Case Control 2012
Genome-wide meta-analysis of common variant differences between men and women
Article / Letter to editor
metadata only
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Pattaro, C.; Kottgen, A.; Teumer, A.; Garnaas, M.; Boger, C.A.; Fuchsberger, C.; ... ; WTCCC2 2012
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Article / Letter to editor
metadata only
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Heid, I.M.; Jackson, A.U.; Randall, J.C.; Winkler, T.W.; Qi, L.; Steinthorsdottir, V.; ... ; North, K.E 2010
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Article / Letter to editor
metadata only
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this... Show moreWaist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 x 10(-9) to P = 1.8 x 10(-40)) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 x 10(-3) to P = 1.2 x 10(-13)). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. Show less