Leiden University Scholarly Publications

Your Search

Enabled Filters

  • (-) = Barkhof, F.

Refine Results

Resource Type

Availability

Creation Date

Show more

Faculty

Collection

Topic

Show more

Author

Show more

Language

Search results

  • RSS Feed
(21 - 40 of 49)

Pages

Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis
Moller, C.; Pijnenburg, Y.A.L.; Flier, W.M. van der; Versteeg, A.; Tijms, B.; Munck, J.C. de; ... ; Wink, A.M. 2016
Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis
Article / Letter to editor
metadata only
Conclusion: The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. The SVM can be used to distinguish disease-specific GM patterns in patients with... Show moreConclusion: The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. The SVM can be used to distinguish disease-specific GM patterns in patients with AD and those with bvFTD as compared with normal aging by using common T1-weighted structural MR imaging. Show less
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease.
Hafkemeijer, A.; Möller, C.; Dopper, E.G.; Jiskoot, L.C.; Van den Berg-Huysmans, A.A.; Van Swieten, J.C.; ... ; Rombouts, S.A. 2016
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease.
Article / Letter to editor
metadata only
Disease-specific patterns of gray matter atrophy in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) overlap with distinct structural covariance networks (SCNs) in... Show moreDisease-specific patterns of gray matter atrophy in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) overlap with distinct structural covariance networks (SCNs) in cognitively healthy controls. This suggests that both types of dementia target specific structural networks. Here, we study SCNs in AD and bvFTD. We used structural magnetic resonance imaging data of 31 AD patients, 24 bvFTD patients, and 30 controls from two centers specialized in dementia. Ten SCNs were defined based on structural covariance of gray matter density using independent component analysis. We studied group differences in SCNs using F-tests, with Bonferroni corrected t-tests, adjusted for age, gender, and study center. Associations with cognitive performance were studied using linear regression analyses. Cross-sectional group differences were found in three SCNs (all P < 0.0025). In bvFTD, we observed decreased anterior cingulate network integrity compared with AD and controls. Patients with AD showed decreased precuneal network integrity compared with bvFTD and controls, and decreased hippocampal network and anterior cingulate network integrity compared with controls. In AD, we found an association between precuneal network integrity and global cognitive performance (P = 0.0043). Our findings show that AD and bvFTD target different SCNs. The comparison of both types of dementia showed decreased precuneal (i.e., default mode) network integrity in AD and decreased anterior cingulate (i.e., salience) network integrity in bvFTD. This confirms the hypothesis that AD and bvFTD have distinct anatomical networks of degeneration and shows that structural covariance gives valuable insights in the understanding of network pathology in dementia. Hum Brain Mapp 37:978-988, 2016. © 2015 Wiley Periodicals, Inc. Show less
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease
Hafkemeijer, A.; Moller, C.; Dopper, E.G.P.; Jiskoot, L.C.; Berg-Huysmans, A.A. van den; Swieten, J.C. van; ... ; Rombouts, S.A.R.B. 2016
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease
Article / Letter to editor
metadata only
Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease.
Möller, C.; Hafkemeijer, A.; Pijnenburg, Y.A.; Rombouts, S.A.; Van der Grond, J.; Dopper, E.; ... ; Van der Flier, W.M. 2016
Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease.
Article / Letter to editor
metadata only
We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34... Show moreWe examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients. Show less
Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease
Moller, C.; Hafkemeijer, A.; Pijnenburg, Y.A.L.; Rombouts, S.A.R.B.; Grond, J. van der; Dopper, E.; ... ; Flier, W.M. van der 2016
Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease
Article / Letter to editor
metadata only
Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function
Van Rooden, S.; Buijs, M.; Van Vliet, M.E.; Versluis, M.J.; Webb, A.G.; Oleksik, A.M.; ... ; Van der Grond, J. 2016
Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function
Article / Letter to editor
open access
2018-02-16T00:00:00Z
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study
Moller, C.; Hafkemeijer, A.; Pijnenburg, Y.A.L.; Rombouts, S.A.R.B.; Grond, J. van der; Dopper, E.; ... ; Flier, W.M. van der 2015
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study
Article / Letter to editor
metadata only
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study.
Möller, C.; Hafkemeijer, A.; Pijnenburg, Y.A.; Rombouts, S.A.; Van der Grond, J.; Dopper, E.; ... ; Van der Flier, W.M. 2015
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study.
Article / Letter to editor
metadata only
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease
Hafkemeijer, A.; Moller, C.; Dopper, E.G.P.; Jiskoot, L.C.; Schouten, T.M.; Swieten, J.C. van; ... ; Rombouts, S.A.R.B. 2015
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease
Article / Letter to editor
metadata only
7T T-2*-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease
Rooden, S. van; Doan, N.T.; Versluis, M.J.; Goos, J.D.C.; Webb, A.G.; Oleksik, A.M.; ... ; Grond, J. van der 2015
7T T-2*-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease
Article / Letter to editor
metadata only
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease
Hafkemeijer, A.; Möller, C.; Dopper, E.G.; Jiskoot, L.C.; Schouten, T.M.; Van Swieten, J.C.; ... ; Rombouts, S.A. 2015
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease
Article / Letter to editor
metadata only
The Dutch Parelsnoer Institute - Neurodegenerative diseases; methods, design and baseline results
Aalten, P.; Ramakers, I.H.G.B.; Biessels, G.J.; Deyn, P.P. de; Koek, H.L.; OldeRikkert, M.G.M.; ... ; Flier, W.M. van der 2014
The Dutch Parelsnoer Institute - Neurodegenerative diseases; methods, design and baseline results
Article / Letter to editor
metadata only
Resting-State Functional MR Imaging: A New Window to the Brain
Barkhof, F.; Haller, S.; Rombouts, S.A.R.B. 2014
Resting-State Functional MR Imaging: A New Window to the Brain
Article / Letter to editor
metadata only
Amyloid and its association with default network integrity in Alzheimer's disease
Adriaanse, S.M.; Sanz-Arigita, E.J.; Binnewijzend, M.A.A.; Ossenkoppele, R.; Tolboom, N.; Assema, D.M.E. van; ... ; Berckel, B.N.M. van 2014
Amyloid and its association with default network integrity in Alzheimer's disease
Article / Letter to editor
metadata only
White Matter Hyperintensities and Cognitive Impairment During Electroconvulsive Therapy in Severely Depressed Elderly Patients
Oudega, M.L.; Exel, E. van; Wattjes, M.P.; Comijs, H.C.; Scheltens, P.; Barkhof, F.; ... ; Stek, M.L. 2014
White Matter Hyperintensities and Cognitive Impairment During Electroconvulsive Therapy in Severely Depressed Elderly Patients
Article / Letter to editor
metadata only
Prevalence of cortical superficial siderosis in a memory clinic population
Zonneveld, H.I.; Goos, J.D.C.; Wattjes, M.P.; Prins, N.D.; Scheltens, P.; Flier, W.M. van der; ... ; Barkhof, F. 2014
Prevalence of cortical superficial siderosis in a memory clinic population
Article / Letter to editor
metadata only
Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging
Rooden, S. van; Goos, J.D.C.; Opstal, A.M. van; Versluis, M.J.; Webb, A.G.; Blauw, G.J.; ... ; Grond, J. van der 2014
Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging
Article / Letter to editor
metadata only
Associations between Magnetic Resonance Imaging Measures and Neuropsychological Impairment in Early and Late Onset Alzheimer's Disease
Vlies, A.E. van der; Staekenborg, S.S.; Admiraal-Behloul, F.; Prins, N.D.; Barkhof, F.; Vrenken, H.; ... ; Flier, W.M. van der 2013
Associations between Magnetic Resonance Imaging Measures and Neuropsychological Impairment in Early and Late Onset Alzheimer's Disease
Article / Letter to editor
metadata only
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Wardlaw, J.M.; Smith, E.E.; Biessels, G.J.; Cordonnier, C.; Fazekas, F.; Frayne, R.; ... ; STand Reporting Vasc Changes 2013
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Article / Letter to editor
metadata only
Coil-treated Aneurysms: Decision Making Regarding Additional Treatment Based on Findings of MR Angiography and Intraarterial DSA
Schaafsma, J.D.; Velthuis, B.K.; Berg, R. van den; Brouwer, P.A.; Majoie, C.B.L.M.; Barkhof, F.; ... ; Rinkel, G.J.E. 2012
Coil-treated Aneurysms: Decision Making Regarding Additional Treatment Based on Findings of MR Angiography and Intraarterial DSA
Article / Letter to editor
metadata only

Pages