Leiden University Scholarly Publications

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A bispecific gd T-cell engager targeting EGFR activates a potent Vg9Vd2 T cell-mediated immune response against EGFR-expressing tumors
Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing
Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells
Amino acids at position 5 in the peptide/MHC binding region of a public virus-specific TCR are completely inter-changeable without loss of function
Identification of functional HLA-A*01:01-restricted Epstein-Barr latent membrane protein 2-Specific T-Cell receptors
Public T-Cell Receptors (TCRs) revisited by analysis of the magnitude of identical and highly-similar TCRs in virus-specific T-Cell repertoires of healthy individuals
Single-cell transcriptomics reveals discrete steps in regulatory T cell development in the human thymus
GPA33 is expressed on multiple human blood cell types and distinguishes CD4(+) central memory T cells with and without effector function
Magnitude of off-target allo-HLA reactivity by third-party donor-derived virus-specific T cells is dictated by HLA-restriction
T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-gamma, TNF-alpha or IL-2 production
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation
GPA33
Determining the extent of maternal-foetal chimerism in cord blood
The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity
Isolation and Validation of the First Functional HLA-a*01:01 Restricted EBV-LMP2 Specific T Cells for Treatment of EBV Associated Type II/III Lymphomas