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Do senescence markers correlate in vitro and in situ within individual human donors?
Waaijer, M.E.C.; Gunn, D.A.; Heemst, D. van; Slagboom, P.E.; Sedivy, J.M.; Dirks, R.W.; ... ; Maier, A.B. 2018
Do senescence markers correlate in vitro and in situ within individual human donors?
Article / Letter to editor
open access
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process
Bacalini, M.G.; Deelen, J.; Pirazzini, C.; Cecco, M. de; Giuliani, C.; Lanzarini, C.; ... ; Garagnani, P. 2017
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process
Article / Letter to editor
metadata only
The number of p16INK4a positive cells in human skin reflects biological age
Waaijer, M.E.C.; Parish, W.E.; Strongitharm, B.H.; Heemst, D. van; Slagboom, P.E.; Craen, A.J.M. de; ... ; Maier, A.B. 2012
The number of p16INK4a positive cells in human skin reflects biological age
Article / Letter to editor
metadata only
The number of p16INK4a positive cells in human skin reflects biological age
Waaijer, M.E.C.; Parish, W.E.; Strongitharm, B.H.; Heemst, D. van; Slagboom, P.E.; Craen, A.J.M. de; ... ; Maier, A.B. 2012
The number of p16INK4a positive cells in human skin reflects biological age
Article / Letter to editor
metadata only
The number of p16INK4a positive cells in human skin reflects biological age
Waaijer, M.E.C.; Parish, W.E.; Strongitharm, B.H.; Heemst, D. van; Slagboom, P.E.; Craen, A.J.M. de; ... ; Maier, A.B. 2012
The number of p16INK4a positive cells in human skin reflects biological age
Article / Letter to editor
metadata only
Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than... Show moreCellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin. Show less