The use of LVEF in quantifying LV systolic dysfunction, is subject to a number of limitations, many of which can partially be overcome by speckle tracking echocardiography. The best-validated... Show moreThe use of LVEF in quantifying LV systolic dysfunction, is subject to a number of limitations, many of which can partially be overcome by speckle tracking echocardiography. The best-validated parameter of LV systolic function is LV GLS, for which ample evidence has accumulated to support its use in diagnosis and risk-stratification of various cardiac diseases affecting the LV. Speckle tracking echocardiography is currently transitioning from an experimental to a routine technique, and is recommended in several clinical scenarios, particularly in those where regular surveillance of LV systolic function has therapeutic implications.Furthermore, echocardiographic evaluation of patients with ischemic heart disease remains pivotal in both the acute setting of STEMI patients and at follow up. New advances in echocardiographic software enables for more comprehensive analysis of the LV. Application of this new data in addition to conventional parameters could provide more and better prognostic information. Using this strategy, patients after STEMI could be identified early for more aggressive and more targeted treatment, or identify patients at risk whom are in need of more intensive follow up. Also, echocardiography could be an additional tool to identify patients that may benefit from treatment strategies. Show less
In this thesis the prognostic value of the new echocardiographic techniques 'speckle tracking strain' and 'myocardial work' was evaluated in patients with hypertrophic cardiomyopathy and primary... Show moreIn this thesis the prognostic value of the new echocardiographic techniques 'speckle tracking strain' and 'myocardial work' was evaluated in patients with hypertrophic cardiomyopathy and primary mitral regurgitation. These parameters were indenpendently associated with outcome in these patients. Furthermore, the pathophysiology and hereditary component of primary mitral valve disease were discussed. Show less
The objectives of this thesis were to elucidate the pathogenesis of metabolic heart disease, evaluate the associated changes in myocardial structure and contractile function, and determine the long... Show moreThe objectives of this thesis were to elucidate the pathogenesis of metabolic heart disease, evaluate the associated changes in myocardial structure and contractile function, and determine the long-term prognostic implications of subclinical myocardial dysfunction on all-cause mortality. Show less
