The main goal of this thesis was to develop methods for automated segmentation, registration and classification of the carotid artery vessel wall and plaque components using multi-sequence MR... Show moreThe main goal of this thesis was to develop methods for automated segmentation, registration and classification of the carotid artery vessel wall and plaque components using multi-sequence MR vessel wall images to assess atherosclerosis. First, a general introduction into atherosclerosis and different stages of the disease were described including the importance to differentiate between stable and vulnerable plaques. Several non-invasive imaging techniques were discussed and the advantages of multi-sequence MRI were highlighted. Different novel automated image segmentation and registration techniques for analysis of the MRI images have been developed. A 3D vessel model to automatically segment the vessel wall was presented. Automated image registration was applied to correct for patient movement during the acquisition of an MRI scan and between MRI scans. The last topic is the automatic classification of the different plaque components which can be present inside the vessel wall. All techniques were developed and validated using relevant patient data and reference standards. The work presented is an important contribution to the automated analysis of multi-sequence MR vessel wall imaging of the carotid artery. These techniques can speed up the current manual analysis and are potentially more accurate and more reproducible. Show less
The study addresses and explains the issue of negative descriptions of the Arab Other in modern Iranian thought. It attempts to understand and illustrate what the notion of the Arab means for... Show moreThe study addresses and explains the issue of negative descriptions of the Arab Other in modern Iranian thought. It attempts to understand and illustrate what the notion of the Arab means for Iranians and how Arabs are portrayed and by examining how they depicted, It describes why they depicted in modern time in such a way, linking this portrayal to a range of ideologies in modern Iran. In doing this research, the researcher has limited his analysis to a certain body of fiction and non-fiction texts. he has selected writings produced by prominent Iranian authors of a variety of ideological affiliations, including literary works such as short stories, novels, historical stories and works published in academic or semi-academic journals, as well as some works in the field of historiography, all of which were written in Persian by Iranian writers between the 1850s and the 1950s. In a broader sense, the study offers an analytical model for the understanding of the Iranian notions of Self and Other in the nineteenth and twentieth centuries. It investigates the ethnic and racial attitudes of a number of Iranian writers and thinkers toward Arabs, contributing to an understanding of the way in which the Iranian identity has been shaped in modern times. Show less
